pfp protein (Bacteroides cellulosilyticus) - STRING interaction network

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pfp

Pyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (548 aa)

Predicted Functional Partners:

pgi

0.966

fda

0.925

tkt

0.918

tal

0.917

fbaB

0.913

gmuF

0.912

fbp

0.910

ydjH_1

0.910

ydjH_2

0.910

pfkA_2

0.905

Your Current Organism:

Bacteroides cellulosilyticus

NCBI taxonomy Id: 246787
Other names: B. cellulosilyticus, Bacteroides cellulosilyticus Robert et al. 2007 emend. Hahnke et al. 2016, CCUG 44979, DSM 14838, JCM 15632, strain CRE21

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
fbaB	fbp	BcellWH2_04749	BcellWH2_00680	Fructose-bisphosphate aldolase class 1.	Fructose-1,6-bisphosphatase class 3.	0.903
fbaB	fda	BcellWH2_04749	BcellWH2_04390	Fructose-bisphosphate aldolase class 1.	Fructose-bisphosphate aldolase.	0.916
fbaB	pfkA_2	BcellWH2_04749	BcellWH2_02479	Fructose-bisphosphate aldolase class 1.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.	0.913
fbaB	pfp	BcellWH2_04749	BcellWH2_01002	Fructose-bisphosphate aldolase class 1.	Pyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.913
fbaB	pgi	BcellWH2_04749	BcellWH2_01583	Fructose-bisphosphate aldolase class 1.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.827
fbaB	tal	BcellWH2_04749	BcellWH2_01245	Fructose-bisphosphate aldolase class 1.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.	0.923
fbaB	tkt	BcellWH2_04749	BcellWH2_00937	Fructose-bisphosphate aldolase class 1.	Transketolase; Belongs to the transketolase family.	0.925
fbp	fbaB	BcellWH2_00680	BcellWH2_04749	Fructose-1,6-bisphosphatase class 3.	Fructose-bisphosphate aldolase class 1.	0.903
fbp	fda	BcellWH2_00680	BcellWH2_04390	Fructose-1,6-bisphosphatase class 3.	Fructose-bisphosphate aldolase.	0.921
fbp	gmuF	BcellWH2_00680	BcellWH2_00916	Fructose-1,6-bisphosphatase class 3.	Putative mannose-6-phosphate isomerase GmuF.	0.906
fbp	pfkA_2	BcellWH2_00680	BcellWH2_02479	Fructose-1,6-bisphosphatase class 3.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.	0.910
fbp	pfp	BcellWH2_00680	BcellWH2_01002	Fructose-1,6-bisphosphatase class 3.	Pyrophosphate--fructose 6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.	0.910
fbp	pgi	BcellWH2_00680	BcellWH2_01583	Fructose-1,6-bisphosphatase class 3.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.920
fbp	tal	BcellWH2_00680	BcellWH2_01245	Fructose-1,6-bisphosphatase class 3.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.	0.905
fbp	tkt	BcellWH2_00680	BcellWH2_00937	Fructose-1,6-bisphosphatase class 3.	Transketolase; Belongs to the transketolase family.	0.907
fbp	ydjH_1	BcellWH2_00680	BcellWH2_01335	Fructose-1,6-bisphosphatase class 3.	Putative sugar kinase YdjH.	0.905
fbp	ydjH_2	BcellWH2_00680	BcellWH2_02587	Fructose-1,6-bisphosphatase class 3.	Putative sugar kinase YdjH.	0.905
fda	fbaB	BcellWH2_04390	BcellWH2_04749	Fructose-bisphosphate aldolase.	Fructose-bisphosphate aldolase class 1.	0.916
fda	fbp	BcellWH2_04390	BcellWH2_00680	Fructose-bisphosphate aldolase.	Fructose-1,6-bisphosphatase class 3.	0.921
fda	pfkA_2	BcellWH2_04390	BcellWH2_02479	Fructose-bisphosphate aldolase.	6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.	0.925

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