STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TAM4_1246Cob(I)alamin adenosyltransferase. (175 aa)    
Predicted Functional Partners:
cobQ
Cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
  
 0.996
cobS
Cobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family.
 
 
 0.969
cobD
Adenosylcobinamide-phosphate synthase, CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.
 
  
 0.962
TAM4_1930
ATP:cob(I)alamin adenosyltransferase, PduO.
    
 0.954
TAM4_743
Adenosylcobinamide amidohydrolase.
    
  0.915
TAM4_1100
Ribonucleoside-diphosphate reductase, coenzyme B12-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
 
   
 0.683
TAM4_1278
Conserved hypothetical protein.
       0.575
hisI
Phosphoribosyl-AMP cyclohydrolase / Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.
     
 0.549
TAM4_435
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Belongs to the UPF0284 family.
     
 0.403
Your Current Organism:
Thermococcus sp. AM4
NCBI taxonomy Id: 246969
Other names: T. sp. AM4
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