STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TAM4_970Hypothetical protein. (1135 aa)    
Predicted Functional Partners:
TAM4_499
Protein kinase.
 
 0.996
TAM4_1735
Conserved hypothetical protein.
  
 0.983
smc
Chromosome partition protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family.
 
 
 0.965
radA
DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
   
 0.958
radB
DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.
   
 0.958
mre11
DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
  
 0.949
TAM4_942
DNA repair helicase Rad3.
   
 0.949
TAM4_469
Histone deacetylase.
  
 0.933
cobB
NAD-dependent protein deacetylase of SIR2 family; Belongs to the sirtuin family. Class III subfamily.
  
 0.921
TAM4_1666
Protein-tyrosine phosphatase.
 
 0.903
Your Current Organism:
Thermococcus sp. AM4
NCBI taxonomy Id: 246969
Other names: T. sp. AM4
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.