node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EAW29581.1 | EAW32971.1 | GP2143_10832 | GP2143_16986 | Hypothetical protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family. | A / G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.564 |
EAW29581.1 | polA | GP2143_10832 | GP2143_15781 | Hypothetical protein; COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes; Belongs to the Nudix hydrolase family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.449 |
EAW31254.1 | EAW32673.1 | GP2143_03998 | GP2143_15496 | COG0708 Exonuclease III. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.840 |
EAW31254.1 | EAW32819.1 | GP2143_03998 | GP2143_16226 | COG0708 Exonuclease III. | COG0708 Exonuclease III. | 0.876 |
EAW31254.1 | EAW32971.1 | GP2143_03998 | GP2143_16986 | COG0708 Exonuclease III. | A / G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.835 |
EAW31254.1 | birA | GP2143_03998 | GP2143_18271 | COG0708 Exonuclease III. | Biotin--protein ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.847 |
EAW31254.1 | nth | GP2143_03998 | GP2143_02209 | COG0708 Exonuclease III. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.978 |
EAW31254.1 | polA | GP2143_03998 | GP2143_15781 | COG0708 Exonuclease III. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.827 |
EAW32673.1 | EAW31254.1 | GP2143_15496 | GP2143_03998 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | COG0708 Exonuclease III. | 0.840 |
EAW32673.1 | EAW32819.1 | GP2143_15496 | GP2143_16226 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | COG0708 Exonuclease III. | 0.840 |
EAW32673.1 | EAW32971.1 | GP2143_15496 | GP2143_16986 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | A / G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.651 |
EAW32673.1 | polA | GP2143_15496 | GP2143_15781 | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.995 |
EAW32819.1 | EAW31254.1 | GP2143_16226 | GP2143_03998 | COG0708 Exonuclease III. | COG0708 Exonuclease III. | 0.876 |
EAW32819.1 | EAW32673.1 | GP2143_16226 | GP2143_15496 | COG0708 Exonuclease III. | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.840 |
EAW32819.1 | EAW32971.1 | GP2143_16226 | GP2143_16986 | COG0708 Exonuclease III. | A / G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.833 |
EAW32819.1 | birA | GP2143_16226 | GP2143_18271 | COG0708 Exonuclease III. | Biotin--protein ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.847 |
EAW32819.1 | nth | GP2143_16226 | GP2143_02209 | COG0708 Exonuclease III. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.954 |
EAW32819.1 | polA | GP2143_16226 | GP2143_15781 | COG0708 Exonuclease III. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.827 |
EAW32970.1 | EAW32971.1 | GP2143_16981 | GP2143_16986 | Hypothetical protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | A / G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.756 |
EAW32970.1 | hisB | GP2143_16981 | GP2143_16991 | Hypothetical protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. | COG0131 Imidazoleglycerol-phosphate dehydratase. | 0.520 |