node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEB77685.1 | EEB80256.1 | GPB2148_621 | GPB2148_3070 | 3-deoxy-D-manno-octulosonic-acid transferase subfamily, putative; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | Sugar isomerase, KpsF/GutQ family; [R] COG0517 FOG: CBS domain. | 0.882 |
EEB77685.1 | kdsA | GPB2148_621 | GPB2148_1472 | 3-deoxy-D-manno-octulosonic-acid transferase subfamily, putative; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | [E] COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the KdsA family. | 0.824 |
EEB77685.1 | kdsB | GPB2148_621 | GPB2148_3861 | 3-deoxy-D-manno-octulosonic-acid transferase subfamily, putative; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.977 |
EEB77685.1 | lpxA | GPB2148_621 | GPB2148_2927 | 3-deoxy-D-manno-octulosonic-acid transferase subfamily, putative; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | acyl-(acyl-carrier-protein)-UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.840 |
EEB77685.1 | lpxB | GPB2148_621 | GPB2148_3134 | 3-deoxy-D-manno-octulosonic-acid transferase subfamily, putative; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.844 |
EEB77685.1 | lpxC | GPB2148_621 | GPB2148_3181 | 3-deoxy-D-manno-octulosonic-acid transferase subfamily, putative; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.837 |
EEB77685.1 | lpxD | GPB2148_621 | GPB2148_2992 | 3-deoxy-D-manno-octulosonic-acid transferase subfamily, putative; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.838 |
EEB77685.1 | lpxK | GPB2148_621 | GPB2148_3686 | 3-deoxy-D-manno-octulosonic-acid transferase subfamily, putative; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.997 |
EEB79669.1 | kdsB | GPB2148_3514 | GPB2148_3861 | Transporter, MotA/TolQ/ExbB proton channel family, putative; [U] COG0811 Biopolymer transport proteins. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.858 |
EEB79669.1 | lpxA | GPB2148_3514 | GPB2148_2927 | Transporter, MotA/TolQ/ExbB proton channel family, putative; [U] COG0811 Biopolymer transport proteins. | acyl-(acyl-carrier-protein)-UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.501 |
EEB79669.1 | lpxK | GPB2148_3514 | GPB2148_3686 | Transporter, MotA/TolQ/ExbB proton channel family, putative; [U] COG0811 Biopolymer transport proteins. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.869 |
EEB79669.1 | msbA | GPB2148_3514 | GPB2148_3622 | Transporter, MotA/TolQ/ExbB proton channel family, putative; [U] COG0811 Biopolymer transport proteins. | Lipid A export permease/ATP-binding protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. | 0.799 |
EEB80256.1 | EEB77685.1 | GPB2148_3070 | GPB2148_621 | Sugar isomerase, KpsF/GutQ family; [R] COG0517 FOG: CBS domain. | 3-deoxy-D-manno-octulosonic-acid transferase subfamily, putative; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. | 0.882 |
EEB80256.1 | kdsA | GPB2148_3070 | GPB2148_1472 | Sugar isomerase, KpsF/GutQ family; [R] COG0517 FOG: CBS domain. | [E] COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; Belongs to the KdsA family. | 0.985 |
EEB80256.1 | kdsB | GPB2148_3070 | GPB2148_3861 | Sugar isomerase, KpsF/GutQ family; [R] COG0517 FOG: CBS domain. | 3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. | 0.888 |
EEB80256.1 | lpxA | GPB2148_3070 | GPB2148_2927 | Sugar isomerase, KpsF/GutQ family; [R] COG0517 FOG: CBS domain. | acyl-(acyl-carrier-protein)-UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.863 |
EEB80256.1 | lpxB | GPB2148_3070 | GPB2148_3134 | Sugar isomerase, KpsF/GutQ family; [R] COG0517 FOG: CBS domain. | lipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | 0.869 |
EEB80256.1 | lpxC | GPB2148_3070 | GPB2148_3181 | Sugar isomerase, KpsF/GutQ family; [R] COG0517 FOG: CBS domain. | UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. | 0.859 |
EEB80256.1 | lpxD | GPB2148_3070 | GPB2148_2992 | Sugar isomerase, KpsF/GutQ family; [R] COG0517 FOG: CBS domain. | UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. | 0.847 |
EEB80256.1 | lpxK | GPB2148_3070 | GPB2148_3686 | Sugar isomerase, KpsF/GutQ family; [R] COG0517 FOG: CBS domain. | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). | 0.884 |