STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
OJG44023.1hydroxymethylglutaryl-CoA synthase. (383 aa)    
Predicted Functional Partners:
OJG44022.1
acetyl-CoA C-acetyltransferase.
 0.999
OJG43270.1
Pyruvate:ferredoxin (flavodoxin) oxidoreductase.
     
 0.941
OJG45646.1
Diphosphomevalonate decarboxylase.
 
 
 0.932
OJG45645.1
Mevalonate kinase.
 
 
 0.930
OJG45647.1
Phosphomevalonate kinase.
 
 
 0.908
OJG41984.1
Dihydrolipoamide S-succinyltransferase.
   
 
  0.890
fni
Isopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
 
 0.851
dltC
D-alanine-poly(phosphoribitol) ligase subunit 2; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.
  
 0.817
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.
  
 0.817
acpP-2
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
  
 0.817
Your Current Organism:
Enterococcus hermanniensis
NCBI taxonomy Id: 249189
Other names: CCUG 48100, DSM 17122, E. hermanniensis, Enterococcus hermanniensis Koort et al. 2004, LMG 12317, LMG:12317
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