STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHN51069.12-oxoglutarate dehydrogenase E1 component. (924 aa)    
Predicted Functional Partners:
SHN51053.1
2-oxoglutarate dehydrogenase E2 component; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.999
SHN59996.1
2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase).
 0.999
sucC
succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.990
SHN70384.1
Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase).
 0.988
sucD
succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.986
SHN71607.1
Hypothetical protein.
    
 
 0.985
SHN68196.1
Dihydrolipoamide dehydrogenase.
 
 0.980
SHN58849.1
Dihydrolipoamide dehydrogenase.
  
 0.977
SHN51423.1
Ribose-phosphate pyrophosphokinase.
    
 0.950
SHN71554.1
2-oxoisovalerate dehydrogenase E1 component.
   
 0.949
Your Current Organism:
Flavobacterium fryxellicola
NCBI taxonomy Id: 249352
Other names: CIP 108325, DSM 16209, F. fryxellicola, Flavobacterium fryxellicola Van Trappen et al. 2005 emend. Hahnke et al. 2016, LMG 22022, LMG:22022
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