glr3379 protein (Gloeobacter violaceus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

glr3379

ORF_ID:glr3379; hypothetical protein. (114 aa)

Predicted Functional Partners:

gll4060

0.774

gsr0107

0.773

gll3317

0.773

gsr1647

0.771

gll2630

0.771

cupB

0.770

glr2915

0.770

gll3249

0.769

glr0411

0.768

gsl2837

0.768

Your Current Organism:

Gloeobacter violaceus

NCBI taxonomy Id: 251221
Other names: G. violaceus PCC 7421, Gloeobacter violaceus ATCC 29082, Gloeobacter violaceus PCC 7421, Gloeobacter violaceus str. PCC 7421, Gloeobacter violaceus strain PCC 7421

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cupB	gll3249	gene:10759574	gene:10760758	CupB protein; ORF_ID:gll2081; unknown protein.	ORF_ID:gll3249; unknown protein.	0.702
cupB	gll3317	gene:10759574	gene:10760827	CupB protein; ORF_ID:gll2081; unknown protein.	ORF_ID:gll3317; hypothetical protein.	0.668
cupB	gll4060	gene:10759574	gene:10761578	CupB protein; ORF_ID:gll2081; unknown protein.	ORF_ID:gll4060; hypothetical protein.	0.701
cupB	glr0411	gene:10759574	gene:10757883	CupB protein; ORF_ID:gll2081; unknown protein.	ORF_ID:glr0411; hypothetical protein.	0.775
cupB	glr2915	gene:10759574	gene:10760419	CupB protein; ORF_ID:gll2081; unknown protein.	ORF_ID:glr2915; hypothetical protein.	0.775
cupB	glr3379	gene:10759574	gene:10760890	CupB protein; ORF_ID:gll2081; unknown protein.	ORF_ID:glr3379; hypothetical protein.	0.770
cupB	gsl2837	gene:10759574	gene:10760341	CupB protein; ORF_ID:gll2081; unknown protein.	ORF_ID:gsl2837; hypothetical protein.	0.775
cupB	gsr0107	gene:10759574	gene:10757576	CupB protein; ORF_ID:gll2081; unknown protein.	ORF_ID:gsr0107; hypothetical protein.	0.656
cupB	gsr1647	gene:10759574	gene:10759137	CupB protein; ORF_ID:gll2081; unknown protein.	ORF_ID:gsr1647; hypothetical protein.	0.595
gll2630	gll3249	gene:10760130	gene:10760758	ORF_ID:gll2630; hypothetical protein.	ORF_ID:gll3249; unknown protein.	0.680
gll2630	gll3317	gene:10760130	gene:10760827	ORF_ID:gll2630; hypothetical protein.	ORF_ID:gll3317; hypothetical protein.	0.593
gll2630	gll4060	gene:10760130	gene:10761578	ORF_ID:gll2630; hypothetical protein.	ORF_ID:gll4060; hypothetical protein.	0.699
gll2630	glr0411	gene:10760130	gene:10757883	ORF_ID:gll2630; hypothetical protein.	ORF_ID:glr0411; hypothetical protein.	0.775
gll2630	glr2915	gene:10760130	gene:10760419	ORF_ID:gll2630; hypothetical protein.	ORF_ID:glr2915; hypothetical protein.	0.775
gll2630	glr3379	gene:10760130	gene:10760890	ORF_ID:gll2630; hypothetical protein.	ORF_ID:glr3379; hypothetical protein.	0.771
gll2630	gsl2837	gene:10760130	gene:10760341	ORF_ID:gll2630; hypothetical protein.	ORF_ID:gsl2837; hypothetical protein.	0.775
gll2630	gsr0107	gene:10760130	gene:10757576	ORF_ID:gll2630; hypothetical protein.	ORF_ID:gsr0107; hypothetical protein.	0.690
gll2630	gsr1647	gene:10760130	gene:10759137	ORF_ID:gll2630; hypothetical protein.	ORF_ID:gsr1647; hypothetical protein.	0.657
gll3249	cupB	gene:10760758	gene:10759574	ORF_ID:gll3249; unknown protein.	CupB protein; ORF_ID:gll2081; unknown protein.	0.702
gll3249	gll2630	gene:10760758	gene:10760130	ORF_ID:gll3249; unknown protein.	ORF_ID:gll2630; hypothetical protein.	0.680

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.877

expected number of edges:

21

PPI enrichment p-value:

7.17e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

7 of 19

2.08

4.33

1.57e-10

GO:2001295

malonyl-CoA biosynthetic process

2 of 5

2.12

1.02

0.0124

GO:0006814

Sodium ion transport

2 of 7

1.97

0.92

0.0180

GO:0044249

Cellular biosynthetic process

9 of 667

0.65

0.52

0.00085

GO:1901576

Organic substance biosynthetic process

9 of 706

0.62

0.49

0.0013

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

4 of 8

2.22

2.45

1.52e-05

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

5 of 44

1.57

1.73

5.39e-05

GO:0003989

acetyl-CoA carboxylase activity

2 of 2

2.52

1.13

0.0085

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

2 of 3

2.34

1.06

0.0113

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 5

2.12

0.91

0.0198

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

2 of 5

2.12

0.89

0.0219

GO:0005622

Intracellular anatomical structure

10 of 1227

0.43

0.31

0.0219

GO:0005737

Cytoplasm

9 of 1122

0.42

0.29

0.0361

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1452

malonyl-CoA metabolic process, and 3-oxoacyl-[acyl-carrier-protein] synthase activity

7 of 11

2.32

5.37

4.79e-12

CL:1448

Mixed, incl. Fatty acid biosynthetic process, and AMP-binding enzyme C-terminal domain

8 of 32

1.92

4.32

6.31e-12

CL:1454

Fatty acid metabolism, and acetyl-CoA carboxylase activity

5 of 6

2.44

4.17

6.11e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00061

Fatty acid biosynthesis

6 of 15

2.12

4.13

8.47e-10

map01212

Fatty acid metabolism

6 of 21

1.97

3.71

2.29e-09

map00620

Pyruvate metabolism

5 of 70

1.37

1.5

5.01e-05

map01200

Carbon metabolism

5 of 145

1.05

0.88

0.0012

map00780

Biotin metabolism

2 of 14

1.67

0.87

0.0178

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

4 of 9

2.17

2.53

8.98e-06

GOCC:0005737

Cytoplasm

10 of 855

0.59

0.48

0.00068

GOCC:0005622

Intracellular

11 of 1191

0.48

0.4

0.00068

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0444

Lipid biosynthesis

4 of 17

1.89

2.03

5.00e-05

KW-0012

Acyltransferase

3 of 17

1.76

1.37

0.0014

KW-0275

Fatty acid biosynthesis

2 of 6

2.04

1.08

0.0087

KW-0808

Transferase

6 of 311

0.8

0.57

0.0063

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