node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
accC | gll0159 | gene:10759504 | gene:10757628 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.918 |
accC | leuA | gene:10759504 | gene:10757893 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 2-isopropylmalate synthase; ORF_ID:gll0421; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.953 |
accC | leuA-2 | gene:10759504 | gene:10759785 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.953 |
gll0159 | accC | gene:10757628 | gene:10759504 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. | 0.918 |
gll0159 | leuA | gene:10757628 | gene:10757893 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 2-isopropylmalate synthase; ORF_ID:gll0421; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.926 |
gll0159 | leuA-2 | gene:10757628 | gene:10759785 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.926 |
gll1225 | ilvD | gene:10758704 | gene:10760674 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Dihydroxyacid dehydratase; ORF_ID:gll3168; Belongs to the IlvD/Edd family. | 0.982 |
gll1225 | ilvE | gene:10758704 | gene:10760082 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Branched-chain amino acid aminotransferase; ORF_ID:gll2582. | 0.924 |
gll1225 | ilvG | gene:10758704 | gene:10760788 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Acetohydroxyacid synthetase large subunit; ORF_ID:glr3279. | 0.546 |
gll1225 | ilvN | gene:10758704 | gene:10758615 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | Acetolactate synthase small subunit; ORF_ID:gll1136. | 0.496 |
gll1225 | leuA | gene:10758704 | gene:10757893 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 2-isopropylmalate synthase; ORF_ID:gll0421; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.975 |
gll1225 | leuA-2 | gene:10758704 | gene:10759785 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.996 |
gll1225 | leuC | gene:10758704 | gene:10760929 | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.455 |
glr3418 | ilvD | gene:10760930 | gene:10760674 | 3-isopropylmalate dehydratase small subunit; ORF_ID:glr3418; Belongs to the LeuD family. | Dihydroxyacid dehydratase; ORF_ID:gll3168; Belongs to the IlvD/Edd family. | 0.931 |
glr3418 | ilvG | gene:10760930 | gene:10760788 | 3-isopropylmalate dehydratase small subunit; ORF_ID:glr3418; Belongs to the LeuD family. | Acetohydroxyacid synthetase large subunit; ORF_ID:glr3279. | 0.774 |
glr3418 | ilvN | gene:10760930 | gene:10758615 | 3-isopropylmalate dehydratase small subunit; ORF_ID:glr3418; Belongs to the LeuD family. | Acetolactate synthase small subunit; ORF_ID:gll1136. | 0.868 |
glr3418 | leuA | gene:10760930 | gene:10757893 | 3-isopropylmalate dehydratase small subunit; ORF_ID:glr3418; Belongs to the LeuD family. | 2-isopropylmalate synthase; ORF_ID:gll0421; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.984 |
glr3418 | leuA-2 | gene:10760930 | gene:10759785 | 3-isopropylmalate dehydratase small subunit; ORF_ID:glr3418; Belongs to the LeuD family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.988 |
glr3418 | leuC | gene:10760930 | gene:10760929 | 3-isopropylmalate dehydratase small subunit; ORF_ID:glr3418; Belongs to the LeuD family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.999 |
ilvD | gll1225 | gene:10760674 | gene:10758704 | Dihydroxyacid dehydratase; ORF_ID:gll3168; Belongs to the IlvD/Edd family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.982 |