STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Chro_0028PFAM: DNA recombination-mediator protein A; TIGRFAM: DNA protecting protein DprA; COGs: COG0758 Rossmann fold nucleotide-binding protein involved in DNA uptake; InterPro IPR003488; KEGG: ava:Ava_3792 smf protein; PFAM: SMF family protein; SPTR: SMF protein; TIGRFAM: DNA protecting protein DprA. (370 aa)    
Predicted Functional Partners:
Chro_2944
Phosphoribosyltransferase; PFAM: Phosphoribosyl transferase domain; TIGRFAM: comF family protein; COGs: COG1040 amidophosphoribosyltransferase; InterPro IPR000836; KEGG: npu:Npun_F0271 hypothetical protein; PFAM: phosphoribosyltransferase; SPTR: Putative uncharacterized protein.
 
 
 0.923
Chro_4029
PFAM: Magnesium chelatase, subunit ChlI; Lon protease (S16) C-terminal proteolytic domain; TIGRFAM: Mg chelatase-related protein; COGs: COG0606 ATPase with chaperone activity; InterPro IPR000523:IPR003593:IPR004482; KEGG: ava:Ava_0816 Mg chelatase-related protein; PFAM: magnesium chelatase ChlI subunit; SMART: AAA ATPase; SPTR: Mg chelatase-related protein; TIGRFAM: Mg chelatase, subunit ChlI.
 
 0.911
Chro_4941
PFAM: Competence protein; TIGRFAM: ComEC/Rec2-related protein; COGs: COG0658 membrane metal-binding protein; InterPro IPR004477; KEGG: npu:Npun_R1641 ComEC/Rec2-related protein; PFAM: ComEC/Rec2-related protein; SPTR: ComEC/Rec2-related protein; TIGRFAM: ComEC/Rec2-related protein.
 
  
 0.875
Chro_0436
Type 4 prepilin peptidase 1; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.
  
  
 0.779
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
    
 0.709
Chro_0048
PFAM: Protein of unknown function (DUF2466); TIGRFAM: DNA repair protein radc; COGs: COG2003 DNA repair protein; InterPro IPR001405:IPR020891; KEGG: ana:alr2351 DNA repair protein RadC; PFAM: DNA repair protein RadC; SPTR: UPF0758 protein alr2351; TIGRFAM: DNA repair protein RadC; Belongs to the UPF0758 family.
  
  
 0.659
Chro_4232
PFAM: Alkaline phosphatase; COGs: COG1785 Alkaline phosphatase; InterPro IPR001952; KEGG: cch:Cag_0787 alkaline phosphatase; PFAM: Alkaline phosphatase; SMART: Alkaline phosphatase; SPTR: Alkaline phosphatase; Belongs to the alkaline phosphatase family.
  
    0.594
Chro_2686
Periplasmic sensor diguanylate cyclase/phosphodiesterase; PFAM: EAL domain; GGDEF domain; CHASE4 domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000700:IPR001633:IPR000160:IPR 001610:IPR000215:IPR007892:IPR013767; KEGG: ppd:Ppro_2997 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; CHASE4 domain protein; PAS fold domain protein; SMART: EAL domain protein; GG [...]
   
    0.581
Chro_4347
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; HAMP domain; GGDEF domain; CHASE4 domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2200 FOG: EAL domain; InterProIPR000014:IPR000700:IPR001633:IPR003660:IPR 000160:IPR001610:IPR007892:IPR013656; KEGG: npu:Npun_F5467 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; CHASE4 domain protein; histidine kinase HAMP region domain protein; PAS fold-4 domain protein; SMART: EAL domain protein; GGDE [...]
   
    0.581
recG
ATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily.
  
     0.566
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
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