Chro_0230 protein (Chroococcidiopsis thermalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

Chro_0230

PFAM: Glycosyl transferases group 1; COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: npu:Npun_R1073 glycosyl transferase, group 1; PFAM: glycosyl transferase group 1; SPTR: Glycosyl transferase, group 1. (276 aa)

Predicted Functional Partners:

Chro_0229

0.636

Chro_0228

0.417

Your Current Organism:

Chroococcidiopsis thermalis

NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Chro_0228	Chro_0229	LmbE family protein; PFAM: GlcNAc-PI de-N-acetylase; COGs: COG2120 conserved hypothetical protein LmbE homologs; InterPro IPR003737; KEGG: naz:Aazo_3114 LmbE family protein; PFAM: LmbE family protein; SPTR: LmbE family protein.	KEGG: npu:Npun_R1073 glycosyl transferase, group 1; SPTR: Glycosyl transferase, group 1.	0.493
Chro_0228	Chro_0230	LmbE family protein; PFAM: GlcNAc-PI de-N-acetylase; COGs: COG2120 conserved hypothetical protein LmbE homologs; InterPro IPR003737; KEGG: naz:Aazo_3114 LmbE family protein; PFAM: LmbE family protein; SPTR: LmbE family protein.	PFAM: Glycosyl transferases group 1; COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: npu:Npun_R1073 glycosyl transferase, group 1; PFAM: glycosyl transferase group 1; SPTR: Glycosyl transferase, group 1.	0.417
Chro_0229	Chro_0228	KEGG: npu:Npun_R1073 glycosyl transferase, group 1; SPTR: Glycosyl transferase, group 1.	LmbE family protein; PFAM: GlcNAc-PI de-N-acetylase; COGs: COG2120 conserved hypothetical protein LmbE homologs; InterPro IPR003737; KEGG: naz:Aazo_3114 LmbE family protein; PFAM: LmbE family protein; SPTR: LmbE family protein.	0.493
Chro_0229	Chro_0230	KEGG: npu:Npun_R1073 glycosyl transferase, group 1; SPTR: Glycosyl transferase, group 1.	PFAM: Glycosyl transferases group 1; COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: npu:Npun_R1073 glycosyl transferase, group 1; PFAM: glycosyl transferase group 1; SPTR: Glycosyl transferase, group 1.	0.636
Chro_0230	Chro_0228	PFAM: Glycosyl transferases group 1; COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: npu:Npun_R1073 glycosyl transferase, group 1; PFAM: glycosyl transferase group 1; SPTR: Glycosyl transferase, group 1.	LmbE family protein; PFAM: GlcNAc-PI de-N-acetylase; COGs: COG2120 conserved hypothetical protein LmbE homologs; InterPro IPR003737; KEGG: naz:Aazo_3114 LmbE family protein; PFAM: LmbE family protein; SPTR: LmbE family protein.	0.417
Chro_0230	Chro_0229	PFAM: Glycosyl transferases group 1; COGs: COG0438 Glycosyltransferase; InterPro IPR001296; KEGG: npu:Npun_R1073 glycosyl transferase, group 1; PFAM: glycosyl transferase group 1; SPTR: Glycosyl transferase, group 1.	KEGG: npu:Npun_R1073 glycosyl transferase, group 1; SPTR: Glycosyl transferase, group 1.	0.636

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

12

PPI enrichment p-value:

0.000746

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 354

1.79

4.36

4.84e-14

GO:0002183

Cytoplasmic translational initiation

3 of 27

2.39

2.12

0.00010

GO:0006446

Regulation of translational initiation

3 of 52

2.1

1.67

0.00057

GO:0075522

IRES-dependent viral translational initiation

2 of 5

2.94

1.61

0.0012

GO:0001732

Formation of cytoplasmic translation initiation complex

2 of 19

2.36

1.09

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003743

Translation initiation factor activity

7 of 53

2.46

6.09

3.62e-13

GO:0043022

Ribosome binding

3 of 72

1.96

1.33

0.0025

GO:0031369

Translation initiation factor binding

2 of 20

2.34

1.02

0.0130

GO:0003735

Structural constituent of ribosome

3 of 176

1.57

0.85

0.0170

GO:0003723

RNA binding

6 of 1158

1.05

0.83

0.0025

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005850

Eukaryotic translation initiation factor 2 complex

3 of 3

3.34

3.19

1.75e-06

GO:0033290

Eukaryotic 48S preinitiation complex

3 of 16

2.61

2.45

2.82e-05

GO:0005840

Ribosome

5 of 203

1.73

2.11

1.25e-05

GO:0015935

Small ribosomal subunit

3 of 49

2.13

1.8

0.00032

GO:0071541

Eukaryotic translation initiation factor 3 complex, eIF3m

2 of 6

2.86

1.67

0.00094

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18379

Eukaryotic 43S preinitiation complex, and Eukaryotic translation initiation factor 2 complex

4 of 23

2.58

3.09

1.53e-06

CL:18383

Eukaryotic translation initiation factor 3 complex

3 of 11

2.78

2.85

5.49e-06

CL:18365

Translational initiation, and Negative regulation of translational initiation

5 of 86

2.1

2.82

1.53e-06

CL:17695

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

5 of 102

2.03

2.76

1.53e-06

CL:17712

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

3 of 43

2.18

1.89

0.00022

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03013

RNA transport

7 of 283

1.73

3.17

2.11e-09

map03010

Ribosome

3 of 198

1.52

0.95

0.0088

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

7 of 64

2.38

5.95

3.31e-13

MAP-72649

Translation initiation complex formation

7 of 70

2.34

5.87

3.31e-13

MAP-72662

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

7 of 74

2.32

5.81

3.38e-13

MAP-72702

Ribosomal scanning and start codon recognition

7 of 77

2.3

5.76

3.77e-13

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

8 of 129

2.13

5.4

2.41e-13

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005850

Eukaryotic translation initiation factor 2 complex

3 of 8

2.91

2.6

1.80e-05

GOCC:0005852

Eukaryotic translation initiation factor 3 complex

2 of 15

2.47

0.93

0.0198

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 24

2.26

0.88

0.0236

GOCC:0005840

Ribosome

3 of 150

1.64

0.84

0.0205

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0396

Initiation factor

6 of 55

2.38

5.1

3.48e-11

KW-0689

Ribosomal protein

3 of 165

1.6

1.03

0.0065

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08662

Eukaryotic translation initiation factor eIF2A

3 of 3

3.34

3.03

3.31e-06

PF03144

Elongation factor Tu domain 2

2 of 15

2.47

0.83

0.0301

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