STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Chro_0288COGs: COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase); InterPro IPR003594:IPR016781; KEGG: ava:Ava_3633 putative anti-sigma regulatory factor (Ser/Thr protein kinase); PFAM: ATP-binding region ATPase domain protein; SPTR: Putative Anti-Sigma regulatory factor (Ser/Thr protein kinase). (151 aa)    
Predicted Functional Partners:
Chro_2180
Anti-sigma-factor antagonist; PFAM: N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); STAS domain; TIGRFAM: anti-anti-sigma factor; COGs: COG2942 N-acyl-D-glucosamine 2-epimerase; InterPro IPR002645; KEGG: ter:Tery_5018 hypothetical protein; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Anti-sigma-factor antagonist.
  
 
 0.900
Chro_1635
Anti-sigma-factor antagonist; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; COGs: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); InterPro IPR002645; KEGG: npu:Npun_R5561 anti-sigma-factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Anti-sigma factor antagonist.
  
 
 0.891
Chro_4034
Sulfate transporter/antisigma-factor antagonist STAS; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; InterPro IPR002645; KEGG: ava:Ava_4411 anti-sigma-factor antagonist domain-containing protein; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Anti-sigma factor antagonist; manually curated.
  
 
 0.891
Chro_4378
Anti-sigma-factor antagonist; PFAM: STAS domain; TIGRFAM: anti-anti-sigma factor; COGs: COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor); InterPro IPR002645:IPR003658; KEGG: npu:Npun_R3892 anti-sigma-factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS; SPTR: Anti-sigma factor antagonist; TIGRFAM: anti-anti-sigma factor.
  
 
 0.891
Chro_2322
Serine phosphatase; PFAM: Stage II sporulation protein E (SpoIIE); COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR003018:IPR010822:IPR001932; KEGG: ana:all1758 hypothetical protein; PFAM: Stage II sporulation protein E; GAF domain protein; SMART: protein phosphatase 2C domain protein; GAF domain protein; SPTR: All1758 protein.
 
 
 0.856
Chro_5133
PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; Hpt domain; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR003660:IPR003661:IPR003594:IPR 001789:IPR008207:IPR005467; KEGG: amr:AM1_5975 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; histidine kinase HAMP region domain protein; response regulator receiver; Hpt domain protein; SMART: ATP-binding region ATPase domain protein; histidine [...]
  
  
 0.813
Chro_1980
Multi-component transcriptional regulator, winged helix family; PFAM: GGDEF domain; Response regulator receiver domain; Transcriptional regulatory protein, C terminal; Hpt domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR000160:IPR001789:IPR008207:IPR001867; KEGG: amr:AM1_D0171 two-component transcriptional regulator/diguanylate cyclase (GGDEF); PFAM: GGDEF domain containing protein; response regulator receiver; transcriptional regulator domain-containing p [...]
  
  
 0.784
Chro_4774
Diguanylate cyclase with PAS/PAC and GAF sensors; PFAM: GAF domain; GGDEF domain; CHASE3 domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterProIPR000014:IPR000700:IPR000160:IPR003018:IPR 007891:IPR013767:IPR013656:IPR001610; KEGG: npu:Npun_R1685 multi-sensor hybrid histidine kinase; PFAM: GGDEF domain containing protein; GAF domain protein; CHASE3 domain protein; PAS fold domain protein; PAS fold-4 domain protein; SMART: GGDEF domain containing protein; PAS dom [...]
  
 
 0.776
Chro_2686
Periplasmic sensor diguanylate cyclase/phosphodiesterase; PFAM: EAL domain; GGDEF domain; CHASE4 domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000700:IPR001633:IPR000160:IPR 001610:IPR000215:IPR007892:IPR013767; KEGG: ppd:Ppro_2997 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; CHASE4 domain protein; PAS fold domain protein; SMART: EAL domain protein; GG [...]
  
 
 0.749
Chro_4347
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); PFAM: EAL domain; HAMP domain; GGDEF domain; CHASE4 domain; PAS fold; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain; COGs: COG2200 FOG: EAL domain; InterProIPR000014:IPR000700:IPR001633:IPR003660:IPR 000160:IPR001610:IPR007892:IPR013656; KEGG: npu:Npun_F5467 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: EAL domain protein; GGDEF domain containing protein; CHASE4 domain protein; histidine kinase HAMP region domain protein; PAS fold-4 domain protein; SMART: EAL domain protein; GGDE [...]
  
 
 0.749
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
Server load: low (24%) [HD]
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