Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Chro_1978Catalytic domain-containing protein of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requiring enzyme; TIGRFAM: pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterProIPR003016:IPR000276:IPR000089:IPR004167:IPR 001078; KEGG: npu:Npun_F6414 branched-chain alpha-keto acid dehydrogenase subunit E2; PFAM: catalytic domain-containing protein of components of vari [...] (442 aa)    
Predicted Functional Partners:
Chro_1465
Transketolase central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.999
Chro_2880
Dihydrolipoamide dehydrogenase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: dihydrolipoamide dehydrogenase; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterProIPR013027:IPR004099:IPR012999:IPR000815:IPR 006258; KEGG: ana:alr4745 dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Dihydrolipoyl dehydrogenase; TIGRFAM: dihydrolipoam [...]
 0.999
pdhA
Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.998
Chro_2254
PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterPro IPR019810:IPR002020:IPR011278; KEGG: npu:Npun_R5627 citrate synthase; PFAM: Citrate synthase; PRIAM: Citrate (Si)-synthase; SPTR: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.
 
 0.992
Chro_3323
PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR012999:IPR013027:IPR004099:IPR000815; KEGG: cyh:Cyan8802_0963 pyridine nucleotide-disulphide oxidoreductase dimerisation region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Pyridine nucleotide-disulphide oxidoreductase dimerisation region.
 0.986
Chro_2016
PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; TIGRFAM: glutathione-disulfide reductase, plant; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027:IPR000815:IPR012999:IPR004099; KEGG: npu:Npun_F0920 pyridine nucleotide-disulphide oxidoreductase dimerisation region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Pyridine nucleotide-disulphide oxidoreductase d [...]
 0.985
Chro_2017
NADPH-glutathione reductase; Maintains high levels of reduced glutathione.
 0.982
Chro_2604
PFAM: ATP-grasp domain; TIGRFAM: succinyl-CoA synthetase, beta subunit; COGs: COG0045 Succinyl-CoA synthetase beta subunit; InterPro IPR011761:IPR013650:IPR005811; KEGG: ava:Ava_1783 succinyl-CoA synthetase (ADP-forming) beta subunit; PFAM: ATP-grasp domain protein; ATP-citrate lyase/succinyl-CoA ligase; PRIAM: Succinate--CoA ligase (ADP-forming); SPTR: Succinyl-CoA synthetase (ADP-forming) beta subunit.
 
 0.980
Chro_2603
PFAM: CoA binding domain; CoA-ligase; TIGRFAM: succinyl-CoA synthetase, alpha subunit; COGs: COG0074 Succinyl-CoA synthetase alpha subunit; InterPro IPR005810:IPR003781:IPR005811; KEGG: npu:Npun_F5184 CoA-binding domain-containing protein; PFAM: CoA-binding domain protein; ATP-citrate lyase/succinyl-CoA ligase; SPTR: CoA-binding.
 
 0.973
Chro_4052
PFAM: Pyridine nucleotide-disulphide oxidoreductase; Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; COGs: COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3); InterPro IPR013027:IPR001327:IPR004099; KEGG: npu:Npun_F5012 pyridine nucleotide-disulphide oxidoreductase dimerisation region; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; SPTR: Pyridine nucleotide-disulphide oxidoreductase dimerisation region.
 0.973
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.