STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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Coexpression
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[Homology]
Score
Chro_2690Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG5002 Signal transduction histidine kinase; InterProIPR005467:IPR000014:IPR000700:IPR001610:IPR 003661:IPR003594:IPR004358:IPR013655:IPR013656; KEGG: cyc:PCC7424_4549 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; PAS fold-3 domain protein; PAS fold-4 domain protein; SMART: ATP-binding region ATPase domain [...] (742 aa)    
Predicted Functional Partners:
Chro_4846
PFAM: Response regulator receiver domain; GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR016132:IPR005467:IPR001789:IPR000014:IPR 000700:IPR004358:IPR013656:IPR003018:IPR013655:IPR003661:I PR003594:IPR001610; KEGG: npu:Npun_R4748 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; PAS fold-4 domain protein; PAS fold-3 domain protein; respon [...]
 
 
0.972
Chro_2201
PAS/PAC sensor hybrid histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR004358:IPR005467:IPR001789:IPR000014:IPR 000700:IPR003661:IPR003594:IPR013656; KEGG: npu:Npun_F2908 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; response regulator receiver; PAS fold-4 domain protein; SMART: response regulator receiver; A [...]
 
 
0.963
Chro_2691
Multi-component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; Collagen triple helix repeat (20 copies); Hpt domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR008207:IPR005829:IPR001867; KEGG: npu:Npun_F2968 multi-component transcriptional regulator; PFAM: response regulator receiver; transcriptional regulator domain-containing protein; Hpt domain protein; SMART: response regulator receiver; SPTR: Multi [...]
 
 0.963
Chro_4923
GAF sensor hybrid histidine kinase; PFAM: HAMP domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467:IPR001789:IPR003660:IPR004358:IPR 003018:IPR003661:IPR003594:IPR018062; KEGG: cyn:Cyan7425_3768 GAF sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; histidine kinase HAMP region domain protein; response regulator receiver; SMART: ATP-binding region [...]
  
 
0.948
Chro_2026
Multi-sensor signal transduction histidine kinase; PFAM: Response regulator receiver domain; GAF domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR004358:IPR005467:IPR001789:IPR 000700:IPR003018:IPR013656:IPR013655:IPR003661:IPR003594:I PR001610; KEGG: cyn:Cyan7425_4608 multi-sensor signal transduction histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; GAF domain protein; PAS fold-3 [...]
 
 
0.931
Chro_4459
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR001789:IPR001610:IPR003661:IPR003594:IPR 005467:IPR000014:IPR000700:IPR004358:IPR013655; KEGG: cyn:Cyan7425_3771 multi-sensor hybrid histidine kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold-3 domain protein; response regulator receiver; histidine kinase A domain protein; SMART: ATP-binding region ATPase domain protein; histidine kinas [...]
 
 
0.926
Chro_1980
Multi-component transcriptional regulator, winged helix family; PFAM: GGDEF domain; Response regulator receiver domain; Transcriptional regulatory protein, C terminal; Hpt domain; TIGRFAM: diguanylate cyclase (GGDEF) domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR000160:IPR001789:IPR008207:IPR001867; KEGG: amr:AM1_D0171 two-component transcriptional regulator/diguanylate cyclase (GGDEF); PFAM: GGDEF domain containing protein; response regulator receiver; transcriptional regulator domain-containing p [...]
 
 0.921
Chro_4222
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterProIPR005467:IPR001789:IPR000014:IPR000700:IPR 004358:IPR003018:IPR003661:IPR003594:IPR013656; KEGG: npu:Npun_F5679 multi-sensor hybrid multi-kinase; PFAM: ATP-binding region ATPase domain protein; PAS fold-4 domain protein; GAF domain protein; histidine kinase A domain protein; response regulator receiver; SMART: ATP-binding region ATPase d [...]
 
 
0.921
Chro_5472
PFAM: GAF domain; Response regulator receiver domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR003018:IPR000014:IPR001610:IPR003661:IPR 003594:IPR001789:IPR005467:IPR000700:IPR004358:IPR013767; KEGG: ana:alr1968 two-component hybrid sensor and regulator; PFAM: ATP-binding region ATPase domain protein; GAF domain protein; PAS fold domain protein; histidine kinase A domain protein; response regulator receiver; SMART: ATP-binding region [...]
 
 
0.917
Chro_0657
Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterProIPR005467:IPR001789:IPR004358:IPR003018:IPR 003661:IPR003594; KEGG: cyt:cce_0164 two-component sensor histidine kinase; PFAM: ATP-binding region ATPase domain protein; histidine kinase A domain protein; GAF domain protein; response regulator receiver; SMART: ATP-binding region ATPase domain protein; histidine kinase A domain prot [...]
 
 
0.911
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
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