STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Chro_2902PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; Uroporphyrinogen-III synthase HemD; TIGRFAM: uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR003754:IPR003043:IPR006366; KEGG: npu:Npun_R1866 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase. (559 aa)    
Predicted Functional Partners:
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
Chro_0407
Porphobilinogen synthase; PFAM: Delta-aminolevulinic acid dehydratase; COGs: COG0113 Delta-aminolevulinic acid dehydratase; InterPro IPR001731; KEGG: ava:Ava_3297 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; PRIAM: Porphobilinogen synthase; SPTR: Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.995
Chro_3049
Precorrin-2 C20-methyltransferase, cobalt-factor II C20-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: precorrin-2 C20-methyltransferase; COGs: COG2243 Precorrin-2 methylase; InterPro IPR000878:IPR006364:IPR012382; KEGG: cyp:PCC8801_3100 precorrin-2 methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Precorrin-2 C20-methyltransferase; TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 
 0.951
Chro_2859
PFAM: Pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] domain; COGs: COG1251 NAD(P)H-nitrite reductase; InterPro IPR017941:IPR013027:IPR019777; KEGG: rmr:Rmar_0914 FAD-dependent pyridine nucleotide-disulphide oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Rieske [2Fe-2S] iron-sulphur domain; SPTR: Uncharacterized NAD(FAD)-dependent dehydrogenase.
 
  
 0.942
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.941
Chro_5225
uroporphyrinogen-III C-methyltransferase; PFAM: Tetrapyrrole (Corrin/Porphyrin) Methylases; TIGRFAM: uroporphyrin-III C-methyltransferase; COGs: COG0007 Uroporphyrinogen-III methylase; InterPro IPR000878:IPR003043:IPR006366; KEGG: npu:Npun_R1873 uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; SPTR: Uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family.
 
 
0.935
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.924
Chro_5389
Assimilatory nitrite reductase (ferredoxin) precursor; PFAM: Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain; TIGRFAM: precorrin-3B synthase; COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR006066:IPR005117:IPR006067; KEGG: npu:Npun_R1528 ferredoxin-nitrite reductase; PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; PRIAM: Ferredoxin--nitrite reductase; SPTR: Nitrite and sulphite reductase 4Fe-4S subunit NirA.
 
  
 0.912
Chro_3568
Assimilatory nitrite reductase (ferredoxin) precursor; PFAM: Nitrite and sulphite reductase 4Fe-4S domain; Nitrite/Sulfite reductase ferredoxin-like half domain; TIGRFAM: precorrin-3B synthase; COGs: COG0155 Sulfite reductase beta subunit (hemoprotein); InterPro IPR006066:IPR005117:IPR006067; KEGG: ava:Ava_4539 ferredoxin-nitrite reductase; PFAM: nitrite and sulphite reductase 4Fe-4S region; nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein; PRIAM: Ferredoxin--nitrite reductase; SPTR: Assimilatory nitrite reductase (Ferredoxin).
 
  
 0.910
ccsA
Cytochrome c-type biogenesis protein CcsB; Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
  
    0.899
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
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