STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
kbl2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (396 aa)    
Predicted Functional Partners:
Chro_2920
L-threonine 3-dehydrogenase; PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: msv:Mesil_2958 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase.
 
 
 0.965
Chro_4665
N-methylglutamate dehydrogenase subunit C; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Glycine cleavage T-protein C-terminal barrel domain; Aminomethyltransferase folate-binding domain; TIGRFAM: glycine cleavage system T protein; COGs: COG0404 Glycine cleavage system T protein (aminomethyltransferase); InterProIPR013027:IPR000103:IPR003953:IPR006222:IPR 013977; KEGG: bph:Bphy_5916 glycine cleavage T protein (aminomethyl transferase); PFAM: glycine cleavage T protein (aminomethyl transferase); fumarate reductase/succinate dehydrogenase flavoprotein domain protein; Glycine cleav [...]
  
 
 0.939
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
 
 0.935
Chro_4664
N-methylglutamate dehydrogenase subunit D; KEGG: bph:Bphy_5917 hypothetical protein; SPTR: Putative uncharacterized protein.
  
 
 0.929
Chro_5343
8-amino-7-oxononanoate synthase; PFAM: Aminotransferase class I and II; COGs: COG0156 7-keto-8-aminopelargonate synthetase; InterPro IPR004839; KEGG: cyc:PCC7424_2980 aminotransferase class I and II; PFAM: aminotransferase class I and II; PRIAM: 8-amino-7-oxononanoate synthase; SPTR: Aminotransferase, classes I and II superfamily.
  
  
 
0.925
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.920
Chro_4667
N-methylglutamate dehydrogenase subunit A precursor; PFAM: FAD dependent oxidoreductase; TIGRFAM: sarcosine oxidase, beta subunit family, heterotetrameric form; COGs: COG0665 Glycine/D-amino acid oxidase (deaminating); InterPro IPR006076; KEGG: bph:Bphy_5914 FAD dependent oxidoreductase; PFAM: FAD dependent oxidoreductase; SPTR: FAD dependent oxidoreductase.
  
 
 0.906
Chro_2771
Short-chain dehydrogenase/reductase SDR; PFAM: short chain dehydrogenase; COGs: COG4221 Short-chain alcohol dehydrogenase of unknown specificity; InterPro IPR002347:IPR002198; KEGG: ava:Ava_2888 short-chain dehydrogenase/reductase SDR; PFAM: short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
     
  0.900
Chro_4666
PFAM: Sarcosine oxidase, delta subunit family; TIGRFAM: sarcosine oxidase, delta subunit family, heterotetrameric form; COGs: COG4311 Sarcosine oxidase delta subunit; InterPro IPR006279; KEGG: mei:Msip34_2427 sarcosine oxidase delta subunit heterotetrameric; PFAM: Sarcosine oxidase delta subunit heterotetrameric; SPTR: Sarcosine oxidase delta subunit heterotetrameric.
     
  0.900
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
  
 0.835
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
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