STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Chro_2959Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (284 aa)    
Predicted Functional Partners:
Chro_0347
PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK); TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; COGs: COG0801 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; InterPro IPR000550; KEGG: ava:Ava_0949 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK; PRIAM:2-amino-4-hydroxy-6-hydroxymethyldihydropteri dinediphosphokinase; SPTR: 7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK; TIGRFAM:2-amino-4-hydroxy-6-hydroxymethyldihydropte ridinepyrophosphokinase.
 
 0.999
Chro_3433
FolC bifunctional protein; PFAM: Mur ligase family, glutamate ligase domain; Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR001645:IPR013221:IPR004101; KEGG: cyc:PCC7424_0544 FolC bifunctional protein; PFAM: Mur ligase middle domain protein; cytoplasmic peptidoglycan synthetase domain protein; PRIAM: Tetrahydrofolate synthase; SPTR: FolC bifunctional protein; TIGRFAM: FolC bifunctional protein.
 
 0.997
Chro_0581
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 
 0.991
Chro_4172
PFAM: Aminotransferase class IV; COGs: COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; InterPro IPR001544; KEGG: npu:Npun_F4880 aminotransferase, class IV; PFAM: aminotransferase class IV; SPTR: Aminotransferase, class IV; manually curated.
  
 
 0.925
folE
PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; COGs: COG0302 GTP cyclohydrolase I; InterPro IPR018234:IPR020602:IPR001474; KEGG: ana:alr5287 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase 1 1; TIGRFAM: GTP cyclohydrolase I.
  
 0.895
folE-2
PFAM: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; COGs: COG0302 GTP cyclohydrolase I; InterPro IPR018234:IPR020602:IPR001474; KEGG: mar:MAE_22860 GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I/Nitrile oxidoreductase; PRIAM: GTP cyclohydrolase I; SPTR: GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I.
  
 0.892
Chro_3140
PFAM: Glutamine amidotransferase class-I; chorismate binding enzyme; Anthranilate synthase component I, N terminal region; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase; anthranilate synthase, alpha proteobacterial clade; COGs: COG0147 Anthranilate/para-aminobenzoate synthase component I; InterProIPR006805:IPR015890:IPR000991:IPR010112:IPR 017926:IPR006221:IPR006220:IPR011702; KEGG: npu:Npun_R1266 anthranilate synthase; PFAM: Chorismate binding-like; Anthranilate synthase component I domain protein; glutamine amidotransferase class-I; SPT [...]
  
  
 0.731
Chro_5567
PFAM: Glutamine amidotransferase class-I; TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase; COGs: COG0512 Anthranilate/para-aminobenzoate synthase component II; InterProIPR017926:IPR006221:IPR006220:IPR011702:IPR 001317:IPR000991; KEGG: npu:Npun_F1347 glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; SPTR: Glutamine amidotransferase of anthranilate synthase; TIGRFAM: glutamine amidotransferase of anthranilate synthase.
 
  
 0.652
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
 
  
 0.599
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
     
 0.573
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.