Chro_3295 protein (Chroococcidiopsis thermalis)

Nodes:

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second shell of interactors

Node Content

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

Chro_3295

KEGG: cyt:cce_0194 hypothetical protein; SPTR: Putative uncharacterized protein. (80 aa)

Predicted Functional Partners:

Chro_3296

0.578

Chro_3294

0.467

Your Current Organism:

Chroococcidiopsis thermalis

NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Chro_3294	Chro_3295	PFAM: AcrB/AcrD/AcrF family; TIGRFAM: The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; COGs: COG0841 Cation/multidrug efflux pump; InterPro IPR001036:IPR004764; KEGG: mar:MAE_36130 RND multidrug efflux transporter; PFAM: acriflavin resistance protein; SPTR: RND multidrug efflux transporter; TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	KEGG: cyt:cce_0194 hypothetical protein; SPTR: Putative uncharacterized protein.	0.467
Chro_3295	Chro_3294	KEGG: cyt:cce_0194 hypothetical protein; SPTR: Putative uncharacterized protein.	PFAM: AcrB/AcrD/AcrF family; TIGRFAM: The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; COGs: COG0841 Cation/multidrug efflux pump; InterPro IPR001036:IPR004764; KEGG: mar:MAE_36130 RND multidrug efflux transporter; PFAM: acriflavin resistance protein; SPTR: RND multidrug efflux transporter; TIGRFAM: transporter, hydrophobe/amphiphile efflux-1 (HAE1) family; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.	0.467
Chro_3295	Chro_3296	KEGG: cyt:cce_0194 hypothetical protein; SPTR: Putative uncharacterized protein.	GUN4 domain protein; PFAM: GUN4-like; InterPro IPR008629; KEGG: amr:AM1_6149 GUN4-like family protein; PFAM: GUN4 domain protein; SPTR: GUN4-like family protein.	0.578
Chro_3296	Chro_3295	GUN4 domain protein; PFAM: GUN4-like; InterPro IPR008629; KEGG: amr:AM1_6149 GUN4-like family protein; PFAM: GUN4 domain protein; SPTR: GUN4-like family protein.	KEGG: cyt:cce_0194 hypothetical protein; SPTR: Putative uncharacterized protein.	0.578

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007031

Peroxisome organization

11 of 24

2.76

12.45

3.02e-26

GO:0006625

Protein targeting to peroxisome

9 of 13

2.94

10.75

1.75e-21

GO:0015919

Peroxisomal membrane transport

9 of 15

2.88

10.62

1.84e-21

GO:0016558

Protein import into peroxisome matrix

7 of 11

2.91

8.03

5.18e-16

GO:0048137

Spermatocyte division

5 of 16

2.6

4.7

8.82e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000268

Peroxisome targeting sequence binding

3 of 3

3.1

2.63

1.71e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005778

Peroxisomal membrane

10 of 25

2.71

10.96

3.22e-23

GO:0005777

Peroxisome

11 of 99

2.15

7.81

1.79e-21

GO:1990429

Peroxisomal importomer complex

3 of 3

3.1

3.24

1.28e-06

GO:0005779

Integral component of peroxisomal membrane

3 of 10

2.58

2.57

1.60e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:21669930

(2011) A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders.

11 of 33

2.63

10.89

1.00e-23

PMID:21826223

(2011) Drosophila carrying pex3 or pex16 mutations are models of Zellweger syndrome that reflect its symptoms associated with the absence of peroxisomes.

9 of 20

2.76

9.2

6.34e-19

PMID:24263361

(2013) Peroxisomes take shape.

8 of 15

2.83

8.3

9.61e-17

PMID:20156962

(2010) Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation.

8 of 18

2.75

8.0

2.30e-16

PMID:33046344

(2021) Balancing the Opposing Principles That Govern Peroxisome Homeostasis.

8 of 22

2.66

7.64

6.88e-16

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3573

Peroxisome organization

11 of 17

2.91

13.68

6.67e-28

CL:3575

Protein targeting to peroxisome

10 of 12

3.02

12.91

1.19e-25

CL:3577

Protein import into peroxisome matrix

6 of 7

3.04

7.19

3.90e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

dme04146

Peroxisome

11 of 90

2.19

8.29

2.19e-22

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

DME-9603798

Class I peroxisomal membrane protein import

7 of 16

2.74

7.48

2.75e-15

DME-9609507

Protein localization

10 of 88

2.16

7.0

2.78e-18

DME-8866654

E3 ubiquitin ligases ubiquitinate target proteins

5 of 19

2.52

4.53

1.54e-09

DME-9033241

Peroxisomal protein import

6 of 44

2.24

4.49

3.29e-10

DME-1369062

ABC transporters in lipid homeostasis

2 of 20

2.1

0.84

0.0274

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005778

Peroxisomal membrane

10 of 23

2.74

11.16

2.03e-23

GOCC:0005777

Peroxisome

11 of 91

2.19

8.1

9.37e-22

GOCC:1990429

Peroxisomal importomer complex

5 of 5

3.1

6.06

6.77e-12

GOCC:0005782

Peroxisomal matrix

3 of 4

2.98

3.07

2.45e-06

GOCC:0005779

Integral component of peroxisomal membrane

2 of 7

2.56

1.51

0.0017

Drosophila Phenotype (Monarch)

phenotype

description

count in network

strength

signal

false discovery rate

FBcv:0000431

Abnormal meiotic cell cycle

4 of 221

1.36

1.02

0.0033

FBcv:0000665

Abnormal body size

4 of 403

1.1

0.75

0.0084

FBcv:0000425

Increased cell death

4 of 554

0.96

0.58

0.0224

FBcv:0000357

Abnormal size

6 of 1213

0.8

0.56

0.0077

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0576

Peroxisome

2 of 12

2.32

0.92

0.0205

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04757

Pex2 / Pex12 amino terminal region

2 of 3

2.93

1.18

0.0073

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006845

Pex, N-terminal

2 of 3

2.93

0.91

0.0229

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