STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Chro_4527MazG family protein; PFAM: MazG nucleotide pyrophosphohydrolase domain; TIGRFAM: MazG family protein; COGs: COG3956 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain; InterPro IPR004518:IPR011551; KEGG: ava:Ava_2914 nucleoside triphosphate pyrophosphohydrolase; PFAM: MazG nucleotide pyrophosphohydrolase; SPTR: MazG; TIGRFAM: MazG family protein. (273 aa)    
Predicted Functional Partners:
Chro_4995
PFAM: Phosphoribosyl transferase domain; TIGRFAM: hypoxanthine phosphoribosyltransferase; COGs: COG0634 Hypoxanthine-guanine phosphoribosyltransferase; InterPro IPR000836:IPR005904; KEGG: tjr:TherJR_0786 hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase; PRIAM: Hypoxanthine phosphoribosyltransferase; SPTR: Hypoxanthine phosphoribosyltransferase; TIGRFAM: hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
  0.923
Chro_2394
5'-Nucleotidase domain-containing protein; PFAM: 5'-nucleotidase, C-terminal domain; Calcineurin-like phosphoesterase; COGs: COG0737 5'-nucleotidase/2' 3'-cyclic phosphodiesterase and related esterase; InterPro IPR006179:IPR004843:IPR008334; KEGG: ava:Ava_3996 metallophosphoesterase; PFAM: 5'-Nucleotidase domain-containing protein; metallophosphoesterase; SPTR: Metallophosphoesterase; Belongs to the 5'-nucleotidase family.
    
 0.905
Chro_2829
Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
    
  0.905
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
    
  0.905
Chro_2440
PFAM: IMP dehydrogenase / GMP reductase domain; TIGRFAM: IMP dehydrogenase family protein; COGs: COG0516 IMP dehydrogenase/GMP reductase; InterPro IPR005992:IPR001093; KEGG: ana:alr0051 inosine 5-monophosphate dehydrogenase; PFAM: IMP dehydrogenase/GMP reductase; SPTR: IMP dehydrogenase; TIGRFAM: IMP dehydrogenase family protein.
    
 0.903
surE
5'-nucleotidase, exopolyphosphatase, 3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
 0.902
Chro_2965
5'-nucleotidase, exopolyphosphatase, 3'-nucleotidase; PFAM: Survival protein SurE; TIGRFAM: 5'/3'-nucleotidase SurE; COGs: COG0496 acid phosphatase; InterPro IPR002828; KEGG: npu:Npun_R1763 stationary phase survival protein SurE; PFAM: Survival protein SurE; SPTR: Stationary-phase survival protein SurE; TIGRFAM: stationary-phase survival protein SurE.
     
 0.902
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
     
  0.900
Chro_4526
Protein of unknown function DUF2227, metal-binding protein; PFAM: Uncharacterized metal-binding protein (DUF2227); COGs: COG2389 Uncharacterized metal-binding protein; InterPro IPR019250; KEGG: npu:Npun_R2717 hypothetical protein; PFAM: Protein of unknown function DUF2227, metal-binding; SPTR: Putative uncharacterized protein.
       0.665
Chro_1646
PFAM: Thymidylate synthase; TIGRFAM: thymidylate synthase, methanogen type; COGs: COG0207 Thymidylate synthase; InterPro IPR000398; KEGG: naz:Aazo_5011 thymidylate synthase; PFAM: thymidylate synthase; SPTR: Thymidylate synthase.
   
 
 0.612
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
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