Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
gmd-4GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (359 aa)    
Predicted Functional Partners:
fcl
NAD-dependent epimerase/dehydratase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.
 0.989
Chro_4457
PFAM: Nucleotidyl transferase; TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; COGs: COG0836 Mannose-1-phosphate guanylyltransferase; InterPro IPR005835; KEGG: npu:Npun_R5110 nucleotidyl transferase; PFAM: Nucleotidyl transferase; PRIAM: Mannose-1-phosphate guanylyltransferase; SPTR: Nucleotidyl transferase.
  
 
 0.923
Chro_3371
Nucleotidyl transferase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Nucleotidyl transferase; Bacterial transferase hexapeptide (three repeats); Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR018357:IPR005835:IPR001451:IPR005844; KEGG: npu:Npun_R6155 nucleotidyl transferase [...]
  
 
 0.918
Chro_0719
Nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; TIGRFAM: nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR017476:IPR001732:IPR014026:IPR014027; KEGG: dsa:Desal_3469 nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: GDP-mannose 6-dehydrogenase; S [...]
  
 
 0.912
cugP
Nucleotidyl transferase; Catalyzes the formation of UDP-glucose, from UTP and glucose 1-phosphate.
    
 0.902
Chro_4829
PFAM: DegT/DnrJ/EryC1/StrS aminotransferase family; COGs: COG0399 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; InterPro IPR000653; KEGG: cyt:cce_1406 DegT/DnrJ/EryC1/StrS aminotransferase family protein; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; SPTR: DegT/DnrJ/EryC1/StrS aminotransferase family; Belongs to the DegT/DnrJ/EryC1 family.
    
 0.902
Chro_5085
PFAM: EAL domain; Polysaccharide biosynthesis protein; COGs: COG1086 nucleoside-diphosphate sugar epimerase; InterPro IPR003869:IPR001633; KEGG: npu:Npun_F1367 polysaccharide biosynthesis protein CapD; PFAM: polysaccharide biosynthesis protein CapD; EAL domain protein; SMART: EAL domain protein; SPTR: Polysaccharide biosynthesis protein CapD.
  
  
 0.668
Chro_4636
PFAM: NAD dependent epimerase/dehydratase family; COGs: COG0451 Nucleoside-diphosphate-sugar epimerase; InterPro IPR001509; KEGG: cyn:Cyan7425_2184 NAD-dependent epimerase/dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SPTR: NAD-dependent epimerase/dehydratase.
  
 
0.654
Chro_4634
KEGG: ava:Ava_D0047 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.601
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
 
  
   0.498
Your Current Organism:
Chroococcidiopsis thermalis
NCBI taxonomy Id: 251229
Other names: C. thermalis PCC 7203, Chroococcidiopsis sp. ATCC 27900, Chroococcidiopsis sp. PCC 7203, Chroococcidiopsis thermalis PCC 7203, Chroococcidiopsis thermalis str. PCC 7203
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.