node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIS72169.1 | clpP-2 | SAMN05421799_10386 | SAMN05421799_10960 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.865 |
SIS72169.1 | dnaK | SAMN05421799_10386 | SAMN05421799_102291 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.935 |
SIS72169.1 | groS | SAMN05421799_10386 | SAMN05421799_11178 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.595 |
SIS72169.1 | grpE | SAMN05421799_10386 | SAMN05421799_102292 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.775 |
SIS72169.1 | hrcA | SAMN05421799_10386 | SAMN05421799_102293 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.439 |
SIS94000.1 | SIS94018.1 | SAMN05421799_107109 | SAMN05421799_107110 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease ATP-binding subunit ClpE. | 0.994 |
SIS94000.1 | clpP-2 | SAMN05421799_107109 | SAMN05421799_10960 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.865 |
SIS94000.1 | dnaK | SAMN05421799_107109 | SAMN05421799_102291 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.935 |
SIS94000.1 | groS | SAMN05421799_107109 | SAMN05421799_11178 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.595 |
SIS94000.1 | grpE | SAMN05421799_107109 | SAMN05421799_102292 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.775 |
SIS94000.1 | hrcA | SAMN05421799_107109 | SAMN05421799_102293 | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.439 |
SIS94018.1 | SIS94000.1 | SAMN05421799_107110 | SAMN05421799_107109 | ATP-dependent Clp protease ATP-binding subunit ClpE. | ATP-dependent Clp protease ATP-binding subunit ClpE; Belongs to the ClpA/ClpB family. | 0.994 |
SIS94018.1 | clpP-2 | SAMN05421799_107110 | SAMN05421799_10960 | ATP-dependent Clp protease ATP-binding subunit ClpE. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.865 |
SIS94018.1 | dnaK | SAMN05421799_107110 | SAMN05421799_102291 | ATP-dependent Clp protease ATP-binding subunit ClpE. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.935 |
SIS94018.1 | groS | SAMN05421799_107110 | SAMN05421799_11178 | ATP-dependent Clp protease ATP-binding subunit ClpE. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.595 |
SIS94018.1 | grpE | SAMN05421799_107110 | SAMN05421799_102292 | ATP-dependent Clp protease ATP-binding subunit ClpE. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.775 |
SIS94018.1 | hrcA | SAMN05421799_107110 | SAMN05421799_102293 | ATP-dependent Clp protease ATP-binding subunit ClpE. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.439 |
SIT00000.1 | clpP-2 | SAMN05421799_10961 | SAMN05421799_10960 | Cysteine desulfurase. | ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.779 |
SIT00000.1 | dnaK | SAMN05421799_10961 | SAMN05421799_102291 | Cysteine desulfurase. | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.534 |
SIT00000.1 | grpE | SAMN05421799_10961 | SAMN05421799_102292 | Cysteine desulfurase. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.450 |