PV09_01866 protein (Verruconis gallopava) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

PV09_01866

Uncharacterized protein. (559 aa)

Predicted Functional Partners:

PV09_00783

0.991

PV09_01283

0.980

PV09_01216

0.976

PV09_06497

0.966

PV09_05587

0.964

PV09_01664

0.964

PV09_02724

0.962

PV09_03290

0.959

PV09_01049

0.959

PV09_06865

0.959

Your Current Organism:

Verruconis gallopava

NCBI taxonomy Id: 253628
Other names: ATCC 16027, CBS 437.64, CDC 45-492-62, Dactylaria gallopava, MUCL 6683, Ochroconis gallopava, Scolecobasidium gallopavum, V. gallopava, Verruconis gallopava (W.B. Cooke) Samerpitak & de Hoog, 2014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PV09_00783	PV09_01049	A0A0D2BBV4	A0A0D2AN23	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.591
PV09_00783	PV09_01216	A0A0D2BBV4	A0A0D2ANI9	Uncharacterized protein; Belongs to the cytochrome P450 family.	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.	0.967
PV09_00783	PV09_01283	A0A0D2BBV4	A0A0D1Z5X8	Uncharacterized protein; Belongs to the cytochrome P450 family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.980
PV09_00783	PV09_01664	A0A0D2BBV4	A0A0D2B903	Uncharacterized protein; Belongs to the cytochrome P450 family.	3Beta_HSD domain-containing protein.	0.725
PV09_00783	PV09_01866	A0A0D2BBV4	A0A0D1XYW6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.991
PV09_00783	PV09_02724	A0A0D2BBV4	A0A0D1XTZ4	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.824
PV09_00783	PV09_03290	A0A0D2BBV4	A0A0D2AGS6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.622
PV09_00783	PV09_05587	A0A0D2BBV4	A0A0D2AW45	Uncharacterized protein; Belongs to the cytochrome P450 family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.964
PV09_00783	PV09_06497	A0A0D2BBV4	A0A0D1YMJ5	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.967
PV09_00783	PV09_06865	A0A0D2BBV4	A0A0D2AR52	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.626
PV09_01049	PV09_00783	A0A0D2AN23	A0A0D2BBV4	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.591
PV09_01049	PV09_01216	A0A0D2AN23	A0A0D2ANI9	Uncharacterized protein; Belongs to the cytochrome P450 family.	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.	0.969
PV09_01049	PV09_01283	A0A0D2AN23	A0A0D1Z5X8	Uncharacterized protein; Belongs to the cytochrome P450 family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.986
PV09_01049	PV09_01664	A0A0D2AN23	A0A0D2B903	Uncharacterized protein; Belongs to the cytochrome P450 family.	3Beta_HSD domain-containing protein.	0.958
PV09_01049	PV09_01866	A0A0D2AN23	A0A0D1XYW6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.959
PV09_01049	PV09_02724	A0A0D2AN23	A0A0D1XTZ4	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.986
PV09_01049	PV09_03290	A0A0D2AN23	A0A0D2AGS6	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.953
PV09_01049	PV09_05587	A0A0D2AN23	A0A0D2AW45	Uncharacterized protein; Belongs to the cytochrome P450 family.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.963
PV09_01049	PV09_06497	A0A0D2AN23	A0A0D1YMJ5	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.963
PV09_01216	PV09_00783	A0A0D2ANI9	A0A0D2BBV4	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.967

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Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.879

expected number of edges:

10

PPI enrichment p-value:

8.91e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015940

Pantothenate biosynthetic process

3 of 7

2.58

1.81

0.00046

GO:0072330

Monocarboxylic acid biosynthetic process

4 of 111

1.5

1.04

0.0051

GO:0019752

Carboxylic acid metabolic process

6 of 554

0.98

0.67

0.0090

GO:0044281

Small molecule metabolic process

8 of 1051

0.83

0.64

0.0028

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016903

Oxidoreductase activity, acting on the aldehyde or oxo group of donors

3 of 22

2.08

1.27

0.0037

GO:0004029

Aldehyde dehydrogenase (NAD+) activity

2 of 8

2.34

0.77

0.0397

GO:0003824

Catalytic activity

11 of 4151

0.37

0.26

0.0397

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13320

Coenzyme A biosynthesis, and Pantothenate metabolic process

4 of 12

2.47

2.91

2.87e-06

CL:13321

Pantothenate metabolic process, and Ketopantoate reductase PanE/ApbA

3 of 6

2.65

2.31

5.28e-05

CL:13126

Mixed, incl. Metabolism of nucleotides, and Vitamin biosynthetic process

5 of 109

1.61

1.77

5.28e-05

CL:11098

acetate-CoA ligase activity, and Aldehyde dehydrogenase family

2 of 6

2.47

1.06

0.0117

CL:10969

Mixed, incl. Valine, leucine and isoleucine degradation, and Peroxisomal lipid metabolism

3 of 80

1.52

0.76

0.0270

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00770

Pantothenate and CoA biosynthesis

6 of 49

2.03

3.87

1.65e-09

map00410

beta-Alanine metabolism

3 of 33

1.91

1.69

0.00035

map01110

Biosynthesis of secondary metabolites

7 of 812

0.88

0.78

0.00035

map01100

Metabolic pathways

11 of 2836

0.54

0.46

9.74e-05

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