Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
EFL14775.12-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase. (588 aa)    
Predicted Functional Partners:
EFL14774.1
Dihydrolipoyl dehydrogenase.
 0.998
EFL14777.1
Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.993
EFL16216.1
Branched-chain alpha keto acid dehydrogenase E1 beta subunit.
 
 0.993
EFL16233.1
3-methyl-2-oxobutanoate dehydrogenase subunit E1-beta.
 
 0.993
EFL17581.1
Oxoglutarate dehydrogenase (succinyl-transferring), E1 component.
 
0.993
EFL20104.1
Dihydrolipoyl dehydrogenase.
 0.991
EFL14951.1
Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.985
sucC
succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.983
EFL16217.1
Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit.
 
 0.981
EFL16234.1
Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit.
 
 0.981
Your Current Organism:
Streptomyces sp. C
NCBI taxonomy Id: 253839
Other names: S. sp. C
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.