node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDS05347.1 | SDS87895.1 | SAMN05444158_0852 | SAMN05444158_3540 | DNA topoisomerase I. | ATP-dependent DNA helicase, Rep family. | 0.861 |
SDS05347.1 | SDT48869.1 | SAMN05444158_0852 | SAMN05444158_6427 | DNA topoisomerase I. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.609 |
SDS05347.1 | ligA | SAMN05444158_0852 | SAMN05444158_3561 | DNA topoisomerase I. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.675 |
SDS05347.1 | mfd | SAMN05444158_0852 | SAMN05444158_1306 | DNA topoisomerase I. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.549 |
SDS05347.1 | parC | SAMN05444158_0852 | SAMN05444158_0905 | DNA topoisomerase I. | DNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. | 0.711 |
SDS05347.1 | polA | SAMN05444158_0852 | SAMN05444158_5647 | DNA topoisomerase I. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.979 |
SDS05347.1 | recA | SAMN05444158_0852 | SAMN05444158_0305 | DNA topoisomerase I. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.987 |
SDS05347.1 | ruvB | SAMN05444158_0852 | SAMN05444158_5952 | DNA topoisomerase I. | Holliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.465 |
SDS05347.1 | uvrA | SAMN05444158_0852 | SAMN05444158_1219 | DNA topoisomerase I. | Excinuclease ABC subunit A /UvrA family protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.708 |
SDS05347.1 | uvrC | SAMN05444158_0852 | SAMN05444158_6373 | DNA topoisomerase I. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.602 |
SDS87895.1 | SDS05347.1 | SAMN05444158_3540 | SAMN05444158_0852 | ATP-dependent DNA helicase, Rep family. | DNA topoisomerase I. | 0.861 |
SDS87895.1 | SDT48869.1 | SAMN05444158_3540 | SAMN05444158_6427 | ATP-dependent DNA helicase, Rep family. | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | 0.954 |
SDS87895.1 | ligA | SAMN05444158_3540 | SAMN05444158_3561 | ATP-dependent DNA helicase, Rep family. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.841 |
SDS87895.1 | mfd | SAMN05444158_3540 | SAMN05444158_1306 | ATP-dependent DNA helicase, Rep family. | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. | 0.487 |
SDS87895.1 | polA | SAMN05444158_3540 | SAMN05444158_5647 | ATP-dependent DNA helicase, Rep family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.856 |
SDS87895.1 | recA | SAMN05444158_3540 | SAMN05444158_0305 | ATP-dependent DNA helicase, Rep family. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.941 |
SDS87895.1 | ruvB | SAMN05444158_3540 | SAMN05444158_5952 | ATP-dependent DNA helicase, Rep family. | Holliday junction DNA helicase subunit RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. | 0.430 |
SDS87895.1 | uvrA | SAMN05444158_3540 | SAMN05444158_1219 | ATP-dependent DNA helicase, Rep family. | Excinuclease ABC subunit A /UvrA family protein; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. | 0.755 |
SDS87895.1 | uvrC | SAMN05444158_3540 | SAMN05444158_6373 | ATP-dependent DNA helicase, Rep family. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.859 |
SDT48869.1 | SDS05347.1 | SAMN05444158_6427 | SAMN05444158_0852 | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] | DNA topoisomerase I. | 0.609 |