STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0010Putative membrane protein; Similar in its C-terminal region to Mycobacterium leprae hypothetical 32.2 kDa protein MLB1770.07 or ML0007 TR:O32870 (EMBL:Z70722) (303 aa) fasta scores: E(): 9.9e-08, 36.28% id in 113 aa. (114 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.928
DIP1184
Putative secreted protein; Similar to Mycobacterium tuberculosis hypothetical 32.4 kDa protein Rv1698 precursor or MT1737 or MTCI125.20 SWALL:YG98_MYCTU (SWALL:P58212) (314 aa) fasta scores: E(): 4.4e-22, 31.57% id in 304 aa.
  
     0.711
DIP0007
Hypothetical protein; Doubtful CDS. No significant database matches.
       0.695
DIP0008
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 7.1 kDa protein SC10A5.13 TR:O54104 (EMBL:AL021529) (64 aa) fasta scores: E(): 0.18, 52.5% id in 40 aa.
       0.695
DIP1801
Conserved hypothetical protein; Limited database matches. Similar to Mycobacterium tuberculosis hypothetical protein Rv2474c TR:O53201 (EMBL:AL021246) (217 aa) fasta scores: E(): 2.2e-14, 39.59% id in 197 aa.
  
     0.611
DIP2370
Putative secreted protein; Weak but full length similarity to Mycobacterium tuberculosis hypothetical 83.9 kDa protein Rv3909 or MTCY15F10.02c TR:O05436 (EMBL:Z94121) (802 aa) fasta scores: E(): 8.4e-10, 25.54% id in 916 aa.
  
     0.609
DIP1912
Putative secreted protein; Poor database matches. Similar to Mycobacterium leprae probable exported protein ML2195 TR:Q50040 (EMBL:U15182) (283 aa) fasta scores: E(): 0.44, 23.39% id in 265 aa.
  
     0.607
DIP1078
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 23.0 kDa protein Rv3013 or MTV012.27 TR:O53260 (EMBL:AL021287) (218 aa) fasta scores: E(): 2.6e-27, 40.63% id in 219 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3093 TR:AAK47422 (EMBL:AE007128) (240 aa) fasta scores: E(): 2.8e-27, 40.63% id in 219 aa, and to Mycobacterium leprae hypothetical 24.4 kDa protein MLCB637.11c TR:O33103 (EMBL:Z99263) (230 aa) fasta scores: E(): 1.3e-26, 40.18% id in 219 aa, and to Mycobacterium leprae hypothetical protein ML1704 TR:Q9CBR7 (EMB [...]
  
     0.606
DIP2067
Conserved hypothetical protein; Similar to Mycobacterium leprae hypothetical 25.3 kDa protein ML0281 or MLCB4.24 SWALL:O69596 (EMBL:AL023514) (229 aa) fasta scores: E(): 6.1e-08, 36.63% id in 202 aa.
  
    0.594
DIP0579
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 15.3 kDa protein Rv3412 or MT3521 or MTCY78.16C SW:YY12_MYCTU (Q50714) (136 aa) fasta scores: E(): 7.8e-18, 43.36% id in 113 aa.
  
     0.589
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.