Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
thiCThiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (599 aa)    
Predicted Functional Partners:
thiD
Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD or B2103 SW:THID_ECOLI (P76422) (266 aa) fasta scores: E(): 5.5e-30, 44.9% id in 265 aa.
  
 
 0.996
thiE
Putative thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
 0.990
thiG
Thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
  
 0.976
DIP0032
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 6.6 kDa protein SC6E10.02 TR:Q9S2N5 (EMBL:AL109661) (66 aa) fasta scores: E(): 1.1e-06, 36.36% id in 66 aa.
  
  
 0.953
DIP0034
Similar to Escherichia coli adenylyltransferase ThiF or B3992 SW:THIF_ECOLI (P30138) (251 aa) fasta scores: E(): 1.1e-21, 35.86% id in 237 aa.
  
  
 0.931
thiO
Similar to Rhizobium etli putative thiamine biosynthesis oxidoreductase ThiO SW:THIO_RHIET (O34292) (327 aa) fasta scores: E(): 5.4e-09, 31.67% id in 341 aa.
  
  
 0.860
purM
Similar to Escherichia coli phosphoribosylformylglycinamidine cyclo-ligase PurM SW:PUR5_ECOLI (P08178) (344 aa) fasta scores: E(): 1.4e-59, 48.7% id in 347 aa, and to Corynebacterium ammoniagenes 5'-phosphoribosyl-5-aminoimidazole synthetase PurM TR:Q9RHY0 (EMBL:AB003158) (351 aa) fasta scores: E(): 2.2e-108, 78.09% id in 347 aa.
     
 0.801
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
     
  0.800
DIP0492
Putative molybdopterin biosynthesis protein; Similar to Synechococcus sp MTP-synthase sulfurylase MoeB TR:O54307 (EMBL:Y16560) (391 aa) fasta scores: E(): 1.1e-37, 39.56% id in 369 aa.
  
  
 0.711
lytB
Putative penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
     
 0.650
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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