STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0032Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 6.6 kDa protein SC6E10.02 TR:Q9S2N5 (EMBL:AL109661) (66 aa) fasta scores: E(): 1.1e-06, 36.36% id in 66 aa. (66 aa)    
Predicted Functional Partners:
thiG
Thiazole biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
 
 
 0.995
DIP0034
Similar to Escherichia coli adenylyltransferase ThiF or B3992 SW:THIF_ECOLI (P30138) (251 aa) fasta scores: E(): 1.1e-21, 35.86% id in 237 aa.
  
 
 0.955
thiC
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.953
thiE
Putative thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
  
  
 0.952
thiD
Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD or B2103 SW:THID_ECOLI (P76422) (266 aa) fasta scores: E(): 5.5e-30, 44.9% id in 265 aa.
  
  
 0.949
thiO
Similar to Rhizobium etli putative thiamine biosynthesis oxidoreductase ThiO SW:THIO_RHIET (O34292) (327 aa) fasta scores: E(): 5.4e-09, 31.67% id in 341 aa.
 
  
 0.888
DIP0492
Putative molybdopterin biosynthesis protein; Similar to Synechococcus sp MTP-synthase sulfurylase MoeB TR:O54307 (EMBL:Y16560) (391 aa) fasta scores: E(): 1.1e-37, 39.56% id in 369 aa.
  
 
 0.812
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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