STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas9Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans- encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. [...] (1084 aa)    
Predicted Functional Partners:
cas2
Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.984
cas1
Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.962
ruvC
Crossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
      
 0.644
thiD
Similar to Escherichia coli phosphomethylpyrimidine kinase ThiD or B2103 SW:THID_ECOLI (P76422) (266 aa) fasta scores: E(): 5.5e-30, 44.9% id in 265 aa.
      
 0.617
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
      
 0.597
tox
Diphtheria toxin precursor; Identical to previously sequenced Corynephage beta diphtheria toxin precursor SW:DTX_CORBE (P00588) (567 aa) fasta scores: E(): 6.2e-216, 100% id in 560 aa, and to Corynephage omega diphtheria toxin precursor SW:DTX_COROM (P00587) (560 aa) fasta scores: E(): 1.1e-215, 99.82% id in 560 aa. Note: The start codon for DIP0222 is 7 residues downstream of the one in Corynephage beta.
      
 0.582
DIP2325
Putative surface-anchored protein; No significant database matches. Note: Contains a potential sortase anchor site (LAETG) upstream of the C-terminal region transmembrane domain. Also similar to DIP0439, DIP1724, DIP0442 and DIP0443.
  
     0.507
DIP0062
Putative heavy metal-associated transport protein; Similar to Deinococcus radiodurans conserved hypothetical protein DR2452 TR:Q9RRN6 (EMBL:AE002074) (68 aa) fasta scores: E(): 0.0038, 43.103% id in 58 aa, and to Streptococcus pyogenes putative copper chaperone-copper transport operon CopZ or SPY1714 TR:Q99YG6 (EMBL:AE006600) (67 aa) fasta scores: E(): 0.0065, 40.000% id in 60 aa, and to Pseudomonas syringae Plasmid pPaCu1 copper resistance operon ORFH protein TR:Q9KWM7 (EMBL:AB033420) (65 aa) fasta scores: E(): 0.025, 40.000% id in 60 aa, and to Candida albicans copper-transporting p- [...]
  
     0.483
tadA
Putative cytosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
      
 0.427
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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