Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DIP0099Similar to Streptomyces coelicolor putative RNA polymerase sigma factor SCI11.12c TR:Q9S2A7 (EMBL:AL096849) (185 aa) fasta scores: E(): 2.8e-25, 47.36% id in 171 aa, and to Bacillus subtilis RNA polymerase sigma factor SigW SW:SIGW_BACSU (Q45585) (187 aa) fasta scores: E(): 3.9e-10, 31.39% id in 172 aa; Belongs to the sigma-70 factor family. ECF subfamily. (194 aa)    
Predicted Functional Partners:
DIP0098
Putative membrane protein; Weakly similar to Mycobacterium tuberculosis hypothetical 23.9 kDa protein Rv0444c or MTV037.08C TR:O53729 (EMBL:AL021932) (232 aa) fasta scores: E(): 0.004, 25.94% id in 212 aa.
  
 
 0.989
DIP2372
Similar to Pseudomonas fluorescens alternative sigma factor AlgU TR:AAK94006 (EMBL:AF399758) (193 aa) fasta scores: E(): 8.1e-12, 30.1% id in 186 aa, and to Pseudomonas aeruginosa RNA polymerase sigma-H factor AlgU or AlgT or PA0762 SW:RPSH_PSEAE (Q06198) (193 aa) fasta scores: E(): 1.8e-11, 29.03% id in 186 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.917
DIP0101
Putative membrane protein; Similar to Mycobacterium tuberculosis DipZ protein Rv2874 or MT2942 or MTCY274.05 SW:DIPZ_MYCTU (Q10801) (695 aa) fasta scores: E(): 1.6e-43, 43.65% id in 591 aa.
 
   
 0.906
opuBB
Similar to Bacillus subtilis choline transport system permease protein OpuBB or ProW SW:OPBB_BACSU (Q45461) (217 aa) fasta scores: E(): 3e-14, 30.72% id in 192 aa, and to Mycobacterium tuberculosis putative transport system permease Rv3756c or MTV025.104c TR:O69722 (EMBL:AL022121) (239 aa) fasta scores: E(): 1.9e-28, 48.32% id in 209 aa.
  
    0.773
opuBD
Similar to Bacillus subtilis choline transport system permease protein OpuBD or ProZ SW:OPBD_BACSU (P39775) (226 aa) fasta scores: E(): 8.5e-13, 29.44% id in 197 aa, and to Mycobacterium tuberculosis transport system permease Rv3757c or MTV025.105c TR:O69723 (EMBL:AL022121) (229 aa) fasta scores: E(): 4.7e-25, 39.71% id in 209 aa.
  
    0.773
opuBA
Similar to Bacillus subtilis choline transport ATP-binding protein OpuBA or ProV SW:OPBA_BACSU (Q45460) (381 aa) fasta scores: E(): 2.5e-42, 50.58% id in 255 aa, and to Mycobacterium tuberculosis putative ABC transporter ATP-binding protein Rv3758c or MTV025.106c TR:O69724 (EMBL:AL022121) (376 aa) fasta scores: E(): 1.3e-42, 53.62% id in 248 aa.
       0.773
sigC
Similar to Mycobacterium tuberculosis probable RNA polymerase sigma-C factor SigC or Rv2069 or MT2129 or MTCY49.08 SW:RPSC_MYCTU (Q10679) (185 aa) fasta scores: E(): 6.1e-30, 52.24% id in 178 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
0.751
rpoE
Similar to Mycobacterium tuberculosis RNA polymerase sigma-E factor RpoE or SigH or Rv3223c or MT3320 or MTCY07D11.03 SW:RPOE_MYCTU (O05843) (216 aa) fasta scores: E(): 1e-44, 70.33% id in 182 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
0.729
DIP0100
Hypothetical protein; No significant database matches.
       0.693
DIP0577
Putative RNA-polymerase sigma factor; Similar to Mycobacterium tuberculosis probable RNA polymerase sigma-D factor SigD or Rv3414c or MT3523 or MTCY78.15 SW:RPSD_MYCTU (Q50712) (212 aa) fasta scores: E(): 7e-28, 48.58% id in 177 aa, and to Streptomyces coelicolor RNA polymerase sigma-E factor SigE or SCE94.07 SW:RPOE_STRCO (P38133) (176 aa) fasta scores: E(): 0.0002, 28.38% id in 155 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.653
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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