Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (350 aa)    
Predicted Functional Partners:
bioD2
Dethiobiotin synthetase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.997
bioA
Similar to Corynebacterium glutamicum adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA SWALL:BIOA_CORGL (SWALL:P46395) (423 aa) fasta scores: E(): 7.2e-95, 55.68% id in 422 aa, and to Escherichia coli adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA or B0774 SWALL:BIOA_ECOLI (SWALL:P12995) (429 aa) fasta scores: E(): 3.5e-87, 52.98% id in 419 aa; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.987
bioD1
Dethiobiotin synthetase; Similar to Corynebacterium glutamicum dethiobiotin synthetase BioD SWALL:BIOD_CORGL (SWALL:P46397) (224 aa) fasta scores: E(): 4e-08, 38.94% id in 208 aa, and to Streptomyces coelicolor dethiobiotin synthetase BioD SWALL:Q9FCC1 (EMBL:AL391014) (238 aa) fasta scores: E(): 3.6e-06, 28.37% id in 222 aa. Note: Similar to the downstream CDS DIP1192, 222 aa; E(): 1.3e-13; 38.914% identity in 221 aa overlap - possible duplication.
 
 
 0.984
DIP0661
Putative biotin synthesis-related regulatory protein; Similar to C-terminal region of Escherichia coli BirA bifunctional protein BirA or BioR or DhbB or B3973 SW:BIRA_ECOLI (P06709) (321 aa) fasta scores: E(): 2e-15, 32.12% id in 221 aa.
  
 
 0.937
bioB2
Transferase, biotin synthase family; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
  
  
 
0.916
DIP1382
Putative aminotransferase (biotin synthesis related protein); Similar to Bacillus sphaericus 8-amino-7-oxononanoate synthase BioF SWALL:BIOF_BACSH (SWALL:P22806) (389 aa) fasta scores: E(): 8.9e-47, 40.95% id in 376 aa, and to Escherichia coli 8-amino-7-oxononanoate synthase BioF or B0776 SWALL:BIOF_ECOLI (SWALL:P12998) (384 aa) fasta scores: E(): 9.8e-39, 37.39% id in 353 aa.
 
  
 0.874
DIP0106
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 8.6 kDa protein Rv1590 or MT1625 or MTCY336.14c TR:O06600 (EMBL:Z95586) (79 aa) fasta scores: E(): 4.1e-11, 67.24% id in 58 aa.
 
  
 0.872
bioW
Putative biotin synthesis related protein; Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
 
  
 0.802
DIP0104
Putative peptidase; Similar to Streptomyces coelicolor putative peptidase SCI52.18c TR:Q9AD91 (EMBL:AL590507) (445 aa) fasta scores: E(): 1e-31, 32.04% id in 440 aa.
     
 0.705
fas
Putative fatty acid synthase; Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa.
  
  
 0.658
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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