STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0134Putative DNA-repair protein; Similar to Mycobacterium tuberculosis CDC1551 DNA-3-methyladenine glycosidase I MT1248 TR:AAK45505 (EMBL:AE007001) (204 aa) fasta scores: E(): 8.3e-35, 52.71% id in 184 aa, and to Escherichia coli DNA-3-methyladenine glycosylase I Tag or B3549 SW:3MG1_ECOLI (P05100) (187 aa) fasta scores: E(): 1.5e-25, 44.88% id in 176 aa. (195 aa)    
Predicted Functional Partners:
DIP0135
Similar to Mycobacterium tuberculosis putative oxidoreductase Rv0484c or MT0502 or MTCY20G9.10c SW:Y484_MYCTU (Q11150) (251 aa) fasta scores: E(): 1.2e-45, 57.32% id in 232 aa; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
       0.842
DIP1991
Putative membrane protein; Similar to Streptomyces coelicolor putative transmembrane protein SCK7.11c TR:Q9KIM1 (EMBL:AF230489) (312 aa) fasta scores: E(): 4.5e-47, 50.16% id in 301 aa. C-terminal region is similar to Streptococcus pneumoniae hypothetical protein SP2132 TR:AAK76190 (EMBL:AE007502) (335 aa) fasta scores: E(): 8.7e-22, 42.43% id in 304 aa.
  
    0.663
DIP0133
Similar to Escherichia coli alkylated DNA repair protein Alkb or AidD or B2212 SW:ALKB_ECOLI (P05050) (216 aa) fasta scores: E(): 1.4e-12, 35.02% id in 237 aa.
       0.652
DIP0131
Similar to Escherichia coli ATP-dependent helicase HrpB or B0148 SW:HRPB_ECOLI (P37024) (809 aa) fasta scores: E(): 2.6e-40, 35.09% id in 815 aa.
       0.642
DIP1980
Putative DNA repair protein; Similar to Mycobacterium leprae probable DNA glycosylase ML1920 TR:Q9CBJ0 (EMBL:AL583923) (297 aa) fasta scores: E(): 5.3e-52, 51.86% id in 295 aa. N-terminus is similar to the N-terminal region of Escherichia coli A/G-specific adenine glycosylase MutY SW:MUTY_ECOLI (P17802) (350 aa) fasta scores: E(): 2.9e-23, 40.48% id in 205 aa.
     
 0.610
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.596
parA
Similar to Streptomyces coelicolor chromosome partitioning protein ParA TR:Q9RFM1 (EMBL:AF187159) (357 aa) fasta scores: E(): 2.5e-64, 63.6% id in 294 aa, and to Bacillus subtilis sporulation initiation inhibitor protein Soj SW:SOJ_BACSU (P37522) (253 aa) fasta scores: E(): 2.8e-45, 54.15% id in 253 aa.
      
 0.508
mutM
Putative formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
      
 0.491
DIP0132
Similar to Streptomyces coelicolor putative sugar acetyltransferase SCBAC25F8.11c TR:CAC42146 (EMBL:AL592126) (193 aa) fasta scores: E(): 2.2e-24, 44.7% id in 170 aa, and to Escherichia coli galactoside O-acetyltransferase LacA or B0342 SWALL:THGA_ECOLI (SWALL:P07464) (203 aa) fasta scores: E(): 2.3e-21, 36.51% id in 178 aa.
       0.480
DIP0987
Conserved hypothetical protein; Similar to C-terminal region of Streptomyces coelicolor conserved hypothetical protein SCP8.08 TR:Q9FBL3 (EMBL:AL390975) (74 aa) fasta scores: E(): 8.5e-11, 60.37% id in 53 aa.
     
 0.469
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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