Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP0154Putative endopeptidase; Similar to Mycobacterium tuberculosis CDC1551 endopeptidase, peptidase family M13 MT0208 TR:AAK44429 (EMBL:AE006930) (663 aa) fasta scores: E(): 2.9e-89, 46.97% id in 662 aa. (669 aa)    
Predicted Functional Partners:
DIP1798
Putative aminopeptidase; Similar to Streptomyces lividans aminopeptidase N PepN SW:AMPN_STRLI (Q11010) (857 aa) fasta scores: E(): 1.2e-88, 45.27% id in 888 aa, and to Mycobacterium tuberculosis aminopeptidase Rv2467 TR:O53194 (EMBL:AL021246) (861 aa) fasta scores: E(): 1.9e-132, 51.97% id in 885 aa. CDS appears to be extended at the N-terminus in comparison to orthologues. Possible alternative translational start site, although current start has better RBS and extented region contains Pfam hit.
 
   
 0.738
DIP0155
Putative secreted protein; No significant database matches. Possible secreted protein.
       0.697
DIP0156
Putative membrane protein; No significant database matches. Possible membrane protein.
       0.697
DIP0836
Conserved hypothetical protein; Similar to C-terminal region of Mycobacterium tuberculosis CDC1551 peptidase, M23/M37 family MT0977 TR:AAK45225 (EMBL:AE006983) (332 aa) fasta scores: E(): 2.2e-33, 45.25% id in 232 aa.
      
 0.697
DIP0159
Putative transferase; Similar to Mycobacterium tuberculosis CDC1551 arabinosyl transferase MT3902 TR:AAK48268 (EMBL:AE007183) (1098 aa) fasta scores: E(): 1.3e-49, 38.11% id in 1149 aa.
 
    0.609
DIP0157
Putative secreted protein; Similar to Mycobacterium tuberculosis CDC1551 amino acid ABC transporter, amino acid-binding protein, putative MT3866 TR:AAK48230 (EMBL:AE007181) (343 aa) fasta scores: E(): 2.6e-26, 35.69% id in 311 aa.
       0.575
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.553
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
 
      0.522
DIP0364
Similar to Mycobacterium tuberculosis CDC1551 prolyl oligopeptidase family protein MT0473 TR:AAK44697 (EMBL:AE006950) (673 aa) fasta scores: E(): 9.6e-118, 46.64% id in 671 aa.
  
  
 0.469
ruvB
Holliday junction DNA-helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
   
    0.410
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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