Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tadAPutative cytosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (147 aa)    
Predicted Functional Partners:
DIP0246
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 17.9 kDa protein Rv3753c or MTV025.10c TR:O69720 (EMBL:AL022121) (166 aa) fasta scores: E(): 1e-20, 45.57% id in 147 aa; Conserved hypothetical protein.
     
 0.766
hisE
Similar to Corynebacterium glutamicum phosphoribosyl-ATP pyrophosphatase HisE SWALL:HIS2_CORGL (SWALL:Q9Z471) (87 aa) fasta scores: E(): 3e-23, 73.56% id in 87 aa, to the C-terminal region of Bacillus subtilis histidine biosynthesis bifunctional protein [includes: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase] HisI or HisIE SWALL:HIS2_BACSU (SWALL:O34912) (209 aa) fasta scores: E(): 0.023, 32.53% id in 83 aa, and to the C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein [includes: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-A [...]
   
  
 0.754
rsmI
Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
 
    0.684
DIP0245
Putative prephenate dehydrogenase; Similar to Mycobacterium tuberculosis CDC1551 prephenate dehydrogenase MT3861 TR:AAK48225 (EMBL:AE007181) (323 aa) fasta scores: E(): 5.5e-49, 52.31% id in 281 aa, and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) (372 aa) fasta scores: E(): 2.7e-15, 31.9% id in 279 aa.
       0.637
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.595
guaA
GMP synthase [glutamine-hydrolysing]; Catalyzes the synthesis of GMP from XMP.
  
  
 0.590
recF
DNA replication and repair protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
      
 0.519
ribA
Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
     
 0.512
ptsG
Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa.
     
 0.511
cas9
Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans- encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. [...]
      
 0.502
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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