Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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tgtPutative tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form [...] (430 aa)    
Predicted Functional Partners:
gluQ
Putative glutamyl-tRNA synthetase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.
 
  
 0.952
gntP
Gluconate permease; Similar to Corynebacterium glutamicum gluconate permease GntP TR:Q9AL75 (EMBL:AJ296014) (463 aa) fasta scores: E(): 2.9e-113, 69.34% id in 460 aa, and to Bacillus subtilis gluconate permease GntP SW:GNTP_BACSU (P12012) (448 aa) fasta scores: E(): 4.8e-53, 38.58% id in 451 aa.
       0.547
csp1
Putative secreted antigen; Similar to Corynebacterium glutamicum PS1 protein precursor Csp1 SW:CSP1_CORGL (Q01377) (657 aa) fasta scores: E(): 1.8e-147, 57.51% id in 659 aa, and similar to but longer than Mycobacterium intracellulare antigen 85-B precursor FbpB SW:A85B_MYCIT (Q49575) (330 aa) fasta scores: E(): 1.8e-29, 37.18% id in 320 aa.
  
     0.504
secD
Putative protein export membrane protein; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.
 
  
 0.487
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
  
 0.479
DIP0250
Putative membrane protein; Similar to Streptomyces coelicolor putative membrane transport protein sce87.17C TR:Q9RKC1 (EMBL:AL132674) (745 aa) fasta scores: E(): 2.9e-36, 42.48% id in 798 aa.
      0.474
aspS
aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
 
    0.439
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.431
accDA
Similar to Corynebacterium glutamicum putative carboxyltransferase subunit of acetyl-CoA carboxylase AccDA TR:CAC42827 (EMBL:Y17592) (491 aa) fasta scores: E(): 8.9e-58, 55.31% id in 499 aa, and to Escherichia coli acetyl-coenzyme A carboxylase carboxyl transferase subunit beta AccD or DedB or Usg or B2316 or Z3578 or ECS3200 SW:ACCD_ECOLI (P08193) (304 aa) fasta scores: E(): 8.6e-22, 34.89% id in 235 aa.
  
    0.422
hisS
histidyl-tRNA synthetase; Similar to Mycobacterium tuberculosis histidyl-tRNA synthetase HisS or Rv2580c or MT2657 or MTCY227.21 SWALL:SYH_MYCTU (SWALL:Q50641) (423 aa) fasta scores: E(): 1.6e-112, 70.4% id in 419 aa, and to Bacillus subtilis histidyl-tRNA synthetase HisS SWALL:SYH_BACSU (SWALL:O32039) (424 aa) fasta scores: E(): 3.8e-61, 45.63% id in 412 aa.
  
  
 0.415
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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