STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0263Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 43.4 kDa protein Rv3712 or MTV025.060 TR:O69679 (EMBL:AL022121) (413 aa) fasta scores: E(): 2.3e-86, 59.95% id in 412 aa, and to Streptomyces coelicolor putative ligase 2SCG58.12 TR:Q9FCA1 (EMBL:AL391017) (412 aa) fasta scores: E(): 4.3e-59, 43.03% id in 409 aa. (420 aa)    
Predicted Functional Partners:
DIP0262
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 cobyric acid synthase MT3816 TR:AAK48185 (EMBL:AE007178) (231 aa) fasta scores: E(): 1.3e-31, 58.13% id in 246 aa, and to Streptomyces coelicolor hypothetical 26.2 kDa protein 2SCG58.13 TR:Q9FCA0 (EMBL:AL391017) (242 aa) fasta scores: E(): 6.6e-20, 42.85% id in 252 aa.
 0.999
murG
UDP-N-acetylglucosamine-N-acetylmuramyl (pentapeptide); Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
  
 0.950
DIP0264
Putative helicase; Similar to Mycobacterium tuberculosis CDC1551 DNA polymerase III, epsilon subunit MT3814 TR:AAK48182 (EMBL:AE007178) (329 aa) fasta scores: E(): 1.3e-07, 25.37% id in 335 aa, and to Bacillus subtilis probable ATP-dependent helicase DinG homolog SW:DING_BACSU (P54394) (931 aa) fasta scores: E(): 0.48, 24.07% id in 108 aa.
       0.807
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
       0.722
DIP0265
Putative nitroreductase; Similar to Escherichia coli oxygen-insensitive NADPH nitroreductase NfsA or MdaA or Mda18 or B0851 SW:NFSA_ECOLI (P17117) (240 aa) fasta scores: E(): 2e-23, 36.32% id in 223 aa; Belongs to the flavin oxidoreductase frp family.
       0.718
DIP0276
Putative membrane protein; Similar to Corynebacterium glutamicum hypothetical 29.6 kDa protein in leuA-lysC intergenic region SW:YLEU_CORGL (P42459) (270 aa) fasta scores: E(): 4.6e-47, 58.18% id in 220 aa.
 
     0.715
murF
UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.
  
  
 0.646
murD
Putative UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
 
  
 0.577
fas
Putative fatty acid synthase; Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa.
  
  
 0.546
DIP2176
Similar to Mycobacterium leprae putative integral membrane protein Ml2581 TR:Q9CD18 (EMBL:AL583926) (427 aa) fasta scores: E(): 8.6e-14, 27.79% id in 367 aa.
  
   
 0.497
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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