Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
sigCSimilar to Mycobacterium tuberculosis probable RNA polymerase sigma-C factor SigC or Rv2069 or MT2129 or MTCY49.08 SW:RPSC_MYCTU (Q10679) (185 aa) fasta scores: E(): 6.1e-30, 52.24% id in 178 aa; Belongs to the sigma-70 factor family. ECF subfamily. (188 aa)    
Predicted Functional Partners:
cat
Catalase; Similar to Onchocerca volvulus endobacterium catalase Cat SW:CATA_ONCVE (Q27710) (482 aa) fasta scores: E(): 8e-92, 52.24% id in 490 aa.
     
 0.870
DIP2372
Similar to Pseudomonas fluorescens alternative sigma factor AlgU TR:AAK94006 (EMBL:AF399758) (193 aa) fasta scores: E(): 8.1e-12, 30.1% id in 186 aa, and to Pseudomonas aeruginosa RNA polymerase sigma-H factor AlgU or AlgT or PA0762 SW:RPSH_PSEAE (Q06198) (193 aa) fasta scores: E(): 1.8e-11, 29.03% id in 186 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.845
DIP0577
Putative RNA-polymerase sigma factor; Similar to Mycobacterium tuberculosis probable RNA polymerase sigma-D factor SigD or Rv3414c or MT3523 or MTCY78.15 SW:RPSD_MYCTU (Q50712) (212 aa) fasta scores: E(): 7e-28, 48.58% id in 177 aa, and to Streptomyces coelicolor RNA polymerase sigma-E factor SigE or SCE94.07 SW:RPOE_STRCO (P38133) (176 aa) fasta scores: E(): 0.0002, 28.38% id in 155 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.765
DIP0099
Similar to Streptomyces coelicolor putative RNA polymerase sigma factor SCI11.12c TR:Q9S2A7 (EMBL:AL096849) (185 aa) fasta scores: E(): 2.8e-25, 47.36% id in 171 aa, and to Bacillus subtilis RNA polymerase sigma factor SigW SW:SIGW_BACSU (Q45585) (187 aa) fasta scores: E(): 3.9e-10, 31.39% id in 172 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
0.751
sigB
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
   
  
 0.706
DIP1805
Putative membrane protein; Similar to Mycobacterium leprae hypothetical protein ML1998 SW:Y102_MYCLE (P53525) (659 aa) fasta scores: E(): 2e-44, 31.72% id in 665 aa, and to Mycobacterium tuberculosis hypothetical protein Rv0102 SW:Y102_MYCTU (Q10897) (661 aa) fasta scores: E(): 2.2e-44, 30.76% id in 650 aa.
      
 0.692
rpoE
Similar to Mycobacterium tuberculosis RNA polymerase sigma-E factor RpoE or SigH or Rv3223c or MT3320 or MTCY07D11.03 SW:RPOE_MYCTU (O05843) (216 aa) fasta scores: E(): 1e-44, 70.33% id in 182 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
0.679
DIP0710
Similar to Streptomyces coelicolor anti-sigma factor RsrA TR:Q9RL96 (EMBL:AJ010320) (105 aa) fasta scores: E(): 5.5e-06, 35.71% id in 70 aa.
  
 
 0.515
ctaB
Putative farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
      
 0.500
DIP0880
Similar to Xanthomonas campestris probable RNA polymerase sigma factor RfaY SW:RFAY_XANCP (P46358) (217 aa) fasta scores: E(): 9.8e-07, 32.88% id in 149 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
     0.499
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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