STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0293Putative Na+/H+ antiporter subunit; Similar to Pseudomonas aeruginosa probable NADH dehydrogenase PA1054 TR:Q9I4S0 (EMBL:AE004537) (933 aa) fasta scores: E(): 3e-85, 34.395% id in 942 aa, and to Rhizobium meliloti pH adaptation potassium efflux system transmembrane protein TR:CAC47489 (EMBL:AL591792) (999 aa) fasta scores: E(): 5.9e-61, 31.818% id in 968 aa, and to Staphylococcus aureus Na+/H+ antiporter subunit MnhA TR:Q9ZNG6 (EMBL:AB015981) (801 aa) fasta scores: E(): 6.5e-33, 31.750% id in 800 aa. (970 aa)    
Predicted Functional Partners:
DIP0288
Putative membrane protein; No significant database matches.
  
 
 0.999
DIP0289
Putative membrane protein; No significant database matches.
  
 
 0.999
DIP0290
Similar to Vibrio cholerae hypothetical protein VCA0154 TR:Q9KN12 (EMBL:AE004356) (158 aa) fasta scores: E(): 0.0029, 30.588% id in 85 aa.
 
 
 0.999
DIP0291
Similar to Staphylococcus aureus Na+/H+-antiporter subunit MnhD or SA0810 TR:Q9ZNG3 (EMBL:AB015981) (498 aa) fasta scores: E(): 2.4e-35, 29.482% id in 502 aa.
 
 
0.999
DIP0292
Similar to Staphylococcus aureus Na+/H+-antiporter subunit MnhC or SA0811 TR:Q9ZNG4 (EMBL:AB015981) (113 aa) fasta scores: E(): 6.5e-08, 38.889% id in 90 aa.
 
 
 0.999
DIP0997
Putative ATP-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
  
   
 0.875
DIP0294
Putative membrane protein; Similar to Deinococcus radiodurans conserved hypothetical protein DR0075 TR:Q9RY75 (EMBL:AE001870) (1467 aa) fasta scores: E(): 3e-06, 27.568% id in 370 aa.
 
     0.743
DIP1750
Similar to Vibrio cholerae glutathione-regulated potassium-efflux system protein KefB, putative VC0992 TR:Q9KTB1 (EMBL:AE004180) (528 aa) fasta scores: E(): 1.3e-37, 33.26% id in 514 aa; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family.
 
   
 0.697
DIP0286
Two-component regulatory protein; Similar to Klebsiella pneumoniae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_KLEPN (P45605) (229 aa) fasta scores: E(): 1.7e-25, 40.708% id in 226 aa, to Shigella dysenteriae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_SHIDY (P45606) (229 aa) fasta scores: E(): 6.5e-25, 40.265% id in 226 aa, and to Escherichia coli phosphate regulon transcriptional regulatory protein PhoB or B0399 or Z0497 or ECS0449 SW:PHOB_ECOLI (P08402) (229 aa) fasta scores: E(): 6.5e-25, 40.265% id in 226 aa.
   
 
 0.642
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.629
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.