STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0301Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3779 TR:AAK48146 (EMBL:AE007175) (151 aa) fasta scores: E(): 1.3e-30, 63.75% id in 149 aa, and to Streptomyces coelicolor hypothetical 15.7 kDa protein SCH17.09c TR:Q9XA38 (EMBL:AL079353) (155 aa) fasta scores: E(): 2.5e-29, 62.25% id in 151 aa. (154 aa)    
Predicted Functional Partners:
fusA
Elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
    
  0.894
DIP0300
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 6.1 kDa protein SCH17.10c TR:Q9XA37 (EMBL:AL079353) (53 aa) fasta scores: E(): 5.4e-16, 85.71% id in 49 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3780 TR:AAK48147 (EMBL:AE007175) (53 aa) fasta scores: E(): 5.9e-14, 77.08% id in 48 aa.
  
    0.848
whiB
Putative regulatory protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
       0.757
DIP0302
Putative hydrolase; Similar to Mycobacterium tuberculosis putative hydrolase Rv3677c or MTV025.025c TR:O69645 (EMBL:AL022121) (264 aa) fasta scores: E(): 1.1e-18, 40.89% id in 269 aa.
  
    0.750
DIP0298
Putative penicillin-binding secreted protein; Similar to Mycobacterium leprae Pbp1 Pon1 SWALL:P72351 (EMBL:S82044) (821 aa) fasta scores: E(): 4.9e-130, 48.08% id in 757 aa, and to Mycobacterium tuberculosis CDC1551 penicillin-binding protein 1 MT3784 TR:AAK48151 (EMBL:AE007176) (810 aa) fasta scores: E(): 4.8e-134, 48.75% id in 761 aa.
       0.616
rph
Putative ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
  
   0.556
ribD
Putative riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
   0.430
nnrE
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
  
    0.427
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (70%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.