Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP0303Putative transcription regulator; Similar to Corynebacterium glutamicum probable transcription regulator TR:AAK58838 (EMBL:AF293334) (227 aa) fasta scores: E(): 8e-79, 91.18% id in 227 aa, and to Escherichia coli catabolite gene activator Crp or Cap or Csm or B3357 or Z4718 or ECS4208 SW:CRP_ECOLI (P03020) (210 aa) fasta scores: E(): 4.6e-15, 33.68% id in 190 aa. (227 aa)    
Predicted Functional Partners:
DIP0332
Putative adenylate cyclase; Similar to Mycobacterium tuberculosis CDC1551 adenylate cyclase, putative MT3748 TR:AAK48108 (EMBL:AE007173) (549 aa) fasta scores: E(): 5.4e-73, 42.99% id in 507 aa.
 
 0.931
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.865
rpoA
DNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.853
rpoZ
Putative DNA-directed RNA polymerase omega chain; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
 
   0.843
rpoC
DNA-directed RNA polymerase beta' chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.829
glpF
Similar to Bacillus subtilis glycerol uptake facilitator protein GlpF SW:GLPF_BACSU (P18156) (274 aa) fasta scores: E(): 2.1e-23, 45.83% id in 240 aa; Belongs to the MIP/aquaporin (TC 1.A.8) family.
   
 0.758
DIP1889
Similar to Streptomyces coelicolor putative transcriptional regulator SC2G5.15C TR:Q9Z5A8 (EMBL:AL035478) (279 aa) fasta scores: E(): 9.5e-35, 44.89% id in 274 aa, and to Rhizobium meliloti putative transcription regulator protein SMC03015 TR:CAC45219 (EMBL:AL591784) (245 aa) fasta scores: E(): 0.012, 25.55% id in 227 aa.
   
 
 0.743
sigA
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
    
 
 0.733
sigB
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
    
 
 0.733
DIP0369
Putative regulatory protein; Similar to Mycobacterium tuberculosis CDC1551 DNA-binding protein, putative MT0481 TR:AAK44705 (EMBL:AE006950) (474 aa) fasta scores: E(): 2.8e-101, 55.34% id in 477 aa.
      
 0.705
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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