Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (251 aa)    
Predicted Functional Partners:
DIP0633
Similar to Streptomyces coelicolor putative exodeoxyribonuclease SCE87.25c TR:Q9RKB3 (EMBL:AL132674) (274 aa) fasta scores: E(): 2.6e-27, 44.3% id in 307 aa.
 
 0.954
DIP0305
Putative secreted protein; Similar to Mycobacterium tuberculosis CDC1551 thioredoxin-related protein MT3774 TR:AAK48141 (EMBL:AE007175) (227 aa) fasta scores: E(): 7.6e-13, 32.84% id in 204 aa.
  
    0.842
DIP0306
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 26.5 kDa protein SCH17.02c TR:Q9XA45 (EMBL:AL079353) (247 aa) fasta scores: E(): 1.9e-26, 40.08% id in 227 aa.
     
 0.836
DIP0307
Similar to Mycobacterium tuberculosis CDC1551 serine protease MT3772 TR:AAK48139 (EMBL:AE007175) (397 aa) fasta scores: E(): 1.5e-47, 38.19% id in 398 aa.
   
 
 0.799
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.785
DIP0331
Conserved hypothetical protein; Similar to Klebsiella oxytoca YiaX1 TR:AAK69523 (EMBL:AF282849) (315 aa) fasta scores: E(): 4.4e-18, 31.94% id in 313 aa.
  
 
 0.748
DIP2047
Putative exonuclease; Similar to Streptomyces coelicolor putative exonuclease SC3A7.09 SWALL:O86610 (EMBL:AL031155) (259 aa) fasta scores: E(): 4.4e-32, 51.93% id in 258 aa, and to Mycobacterium tuberculosis CDC1551 exodeoxyribonuclease III MT0442 SWALL:AAK44665 (EMBL:AE006947) (291 aa) fasta scores: E(): 1.2e-25, 54.16% id in 264 aa.
  
 0.691
purM
Similar to Escherichia coli phosphoribosylformylglycinamidine cyclo-ligase PurM SW:PUR5_ECOLI (P08178) (344 aa) fasta scores: E(): 1.4e-59, 48.7% id in 347 aa, and to Corynebacterium ammoniagenes 5'-phosphoribosyl-5-aminoimidazole synthetase PurM TR:Q9RHY0 (EMBL:AB003158) (351 aa) fasta scores: E(): 2.2e-108, 78.09% id in 347 aa.
     
 0.666
DIP1250
Putative M18-family aminopeptidase; Similar to Streptomyces coelicolor probable M18-family aminopeptidase 2 ApeB or SCGD3.02 SWALL:Q9XA76 (EMBL:AL096822) (432 aa) fasta scores: E(): 2.9e-75, 46.31% id in 421 aa, and to Mycobacterium leprae probable M18-family aminopeptidase 2 ApeB or PepC or PepX or ML2213 or MLCB5.29 SWALL:Q50022 (EMBL:U15182) (443 aa) fasta scores: E(): 4.7e-53, 38.78% id in 428 aa.
     
 0.637
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
 
  
 
 0.631
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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