STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0306Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 26.5 kDa protein SCH17.02c TR:Q9XA45 (EMBL:AL079353) (247 aa) fasta scores: E(): 1.9e-26, 40.08% id in 227 aa. (245 aa)    
Predicted Functional Partners:
DIP0305
Putative secreted protein; Similar to Mycobacterium tuberculosis CDC1551 thioredoxin-related protein MT3774 TR:AAK48141 (EMBL:AE007175) (227 aa) fasta scores: E(): 7.6e-13, 32.84% id in 204 aa.
  
    0.957
nnrE
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
  
 0.928
DIP1125
Similar to Synechocystis sp. hypothetical 21.9 kDa protein SLL1660 SWALL:P72810 (EMBL:D90901) (194 aa) fasta scores: E(): 2.9e-16, 33.13% id in 166 aa, and to Pseudomonas denitrificans hypothetical 19.2 kDa protein in cobO 3'region SWALL:YCB8_PSEDE (SWALL:P29941) (175 aa) fasta scores: E(): 6.6e-07, 34.24% id in 146 aa.
   
 
 0.863
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
     
 0.848
DIP0307
Similar to Mycobacterium tuberculosis CDC1551 serine protease MT3772 TR:AAK48139 (EMBL:AE007175) (397 aa) fasta scores: E(): 1.5e-47, 38.19% id in 398 aa.
  
 
  0.846
DIP1575
Conserved hypothetical protein; Similar to N-terminal region of Deinococcus radiodurans conserved hypothetical protein DRr1631 TR:Q9RTX1 (EMBL:AE002006) (394 aa) fasta scores: E(): 4.7e-12, 31.28% id in 211 aa.
      
 0.842
rph
Putative ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
    
 0.589
DIP0717
Similar to Mycobacterium leprae putative ATP-dependent RNA helicase RhlE or ML0811 TR:Q9CCH3 (EMBL:AL583919) (544 aa) fasta scores: E(): 2.1e-87, 55.78% id in 441 aa, and to Klebsiella pneumoniae cold-shock dead-box protein A DeaD or CsdA SW:DEAD_KLEPN (P33906) (642 aa) fasta scores: E(): 5.7e-49, 41.91% id in 377 aa.
   
 0.568
deaD
DEAD-box helicase; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.
   
 0.568
DIP1212
Putative RNA helicase; Similar to Streptomyces coelicolor SC10A5.25c protein SWALL:O54116 (EMBL:AL021529) (498 aa) fasta scores: E(): 6.5e-63, 46.93% id in 424 aa, and to Escherichia coli putative ATP-dependent RNA helicase RhlE or B0797 SWALL:RHLE_ECOLI (SWALL:P25888) (454 aa) fasta scores: E(): 7.6e-44, 36.06% id in 452 aa.
   
 0.568
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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