Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP0311Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 30.7 kDa protein Rv3661 or MT3761 or MTV025.009 SW:Y0G1_MYCTU (O69629) (287 aa) fasta scores: E(): 2.2e-40, 45.22% id in 272 aa, and to Streptomyces coelicolor putative morphological differentiation-associated protein SCH5.21 TR:Q9X923 (EMBL:AL035636) (268 aa) fasta scores: E(): 5e-38, 45.8% id in 262 aa. (301 aa)    
Predicted Functional Partners:
DIP0784
Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
 
 
 0.766
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.580
hisF
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.576
hisH
Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
  
  
 0.480
hisA
Similar to Streptomyces coelicolor phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA or SC4G6.19c SW:HIS4_STRCO (P16250) (240 aa) fasta scores: E(): 2.2e-52, 61.6% id in 237 aa, and to Corynebacterium glutamicum phosphoribosylformimino-5-amino-1-phosphoribosyl-4- imidazolecarboxamide isomerase HisA TR:O68602 (EMBL:AF051846) (245 aa) fasta scores: E(): 8.3e-70, 77.68% id in 242 aa.
  
    0.466
hisB
Similar to Corynebacterium glutamicum imidazoleglycerol-phosphate dehydrogenase HisB TR:Q9KJU3 (EMBL:AF160479) (205 aa) fasta scores: E(): 2e-49, 66.33% id in 199 aa, and to Streptomyces coelicolor imidazoleglycerol-phosphate dehydratase HisB or SC4G6.21c SW:HIS7_STRCO (P16247) (197 aa) fasta scores: E(): 1.1e-37, 53.03% id in 198 aa.
  
  
 0.446
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.443
DIP0981
Putative succinyltransferase; Similar to Mycobacterium tuberculosis CDC1551 tetrahydrodipicolinate N-succinyltransferase, putative MT1239 TR:AAK45496 (EMBL:AE007001) (317 aa) fasta scores: E(): 3.2e-46, 46.53% id in 303 aa, and C-terminal region to Corynebacterium glutamicum tetrahydrodipicolinate succinylase DapD TR:O69283 (EMBL:AJ004934) (230 aa) fasta scores: E(): 1.6e-28, 45.2% id in 219 aa. Similar also to DIP0979 (45.614% identity in 285 aa overlap).
  
  
 0.437
dapD
Putative succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.
  
  
 0.422
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
  
 0.412
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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