Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP0363Similar to Streptomyces coelicolor putative metallopeptidase SCD95A.06c TR:Q9KXW8 (EMBL:AL357432) (473 aa) fasta scores: E(): 5.2e-42, 32.16% id in 457 aa. (450 aa)    
Predicted Functional Partners:
DIP0364
Similar to Mycobacterium tuberculosis CDC1551 prolyl oligopeptidase family protein MT0473 TR:AAK44697 (EMBL:AE006950) (673 aa) fasta scores: E(): 9.6e-118, 46.64% id in 671 aa.
     
 0.840
rmlB
Similar to Mycobacterium leprae putative dTDP-(glucose or rhamnose)-4,6-dehydratase RmlB TR:Q9X7A3 (EMBL:AL049491) (331 aa) fasta scores: E(): 8.3e-84, 63.77% id in 334 aa; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.
       0.836
DIP2009
Putative peptide synthase; N-terminal region similar to C-terminal region of Streptomyces lavendulae peptide synthetase SWALL:AAK81825 (EMBL:AF386507) (1531 aa) fasta scores: E(): 1.3e-38, 34.02% id in 814 aa, similar in its full length to Agrobacterium tumefaciens StrC58 AGR_l_3476p SWALL:AAK90311 (EMBL:AE008376) (1344 aa) fasta scores: E(): 6.2e-36, 32.96% id in 1338 aa, and N-terminal region similar to the full length of Amycolatopsis orientalis PCZA361.18 SWALL:O52803 (EMBL:AJ223998) (580 aa) fasta scores: E(): 1.3e-33, 38.2% id in 589 aa. C-terminal region presents low similarity [...]
 
     0.793
DIP0361
Putative bifunctional protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
       0.754
rfbA
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
       0.748
slpA
Surface layer protein A; Similar to Corynebacterium ammoniagenes surface layer protein A SlpA TR:BAB62413 (EMBL:AB055224) (358 aa) fasta scores: E(): 1.4e-69, 52.76% id in 362 aa, and to Mycobacterium tuberculosis antigen 85-A precursor FbpA or MPT44 or Rv3804c or MT3911 or MTV026.09c SW:A85A_MYCTU (P17944) (338 aa) fasta scores: E(): 9.7e-18, 31.56% id in 320 aa.
 
    0.722
pflB
HMMPfam hit to PF02901, Pyruvate formate lyase.
  
     0.517
lpd
Similar to Corynebacterium glutamicum dihydrolipoamide dehydrogenase Lpd TR:Q9Z466 (EMBL:Y16642) (469 aa) fasta scores: E(): 1.1e-135, 78.03% id in 469 aa, and to Zymomonas mobilis dihydrolipoamide dehydrogenase Lpd SW:DLDH_ZYMMO (P50970) (466 aa) fasta scores: E(): 5.7e-66, 43.55% id in 473 aa.
  
 
 0.510
DIP0366
Hypothetical protein; Doubtful CDS. No significant database matches.
       0.492
odhA
2-oxoglutarate dehydrogenase, E1 and E2 components; Similar to Corynebacterium glutamicum 2-oxoglutarate dehydrogenase OdhA TR:P96746 (EMBL:D84102) (1257 aa) fasta scores: E(): 0, 77.37% id in 1242 aa, and to Mycobacterium leprae 2-oxoglutarate dehydrogenase, E1 and E2 components OdhA or ML1095 TR:Q9CC97 (EMBL:AL583920) (1260 aa) fasta scores: E(): 0, 59.37% id in 1253 aa. Similar in the N-terminus to Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) SucB or B0727 or Z0881 or ECS0752 SW:ODO2_ECOLI (P07016) blastp scores: E(): 4 [...]
   
   0.474
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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