STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0398Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 32.7 kDa protein Rv0505c or MT0526 or MTCY20G9.32c SW:Y505_MYCTU (Q11169) (308 aa) fasta scores: E(): 4.7e-52, 59.67% id in 243 aa. (347 aa)    
Predicted Functional Partners:
DIP0907
Putative reductase; Similar to Corynebacterium glutamicum hypothetical 33.0 kDa protein in proB-proA intergenic region SW:YPRA_CORGL (P45637) (304 aa) fasta scores: E(): 7.5e-48, 45.3% id in 309 aa, and to Escherichia coli 2-ketogluconate reductase TkrA or B3553 SW:TKRA_ECOLI (P37666) (324 aa) fasta scores: E(): 1.4e-13, 31.57% id in 247 aa.
  
 
 0.855
DIP0784
Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine.
 
 
 0.854
serA
Similar to Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase SerA or Rv2996c or MT3074 or MTV012.10 SW:SERA_MYCTU (O53243) (528 aa) fasta scores: E(): 3.6e-129, 67.56% id in 521 aa, and to Homo sapiens D-3-phosphoglycerate dehydrogenase PhgDH SW:SERA_HUMAN (O43175) (533 aa) fasta scores: E(): 1.4e-43, 34.47% id in 438 aa; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  
 
 0.782
DIP0399
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 10.7 kDa protein Rv0508 or MT0529 or MTCY20G9.35 SW:Y508_MYCTU (Q11172) (97 aa) fasta scores: E(): 2.7e-08, 40.74% id in 81 aa.
 
     0.741
hemA
Putative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
       0.589
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
       0.589
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.577
hisF
Imidazole glycerol phosphate synthase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.569
DIP0402
Similar to Mycobacterium leprae possible uroporphyrin-III C-methyltransferase HemD or ML2420 TR:Q9CB60 (EMBL:AL583925) (563 aa) fasta scores: E(): 9.3e-91, 52.81% id in 551 aa.
  
    0.547
hemB
Similar to Streptomyces coelicolor delta-aminolevulinic acid dehydratase HemB or SCE68.09c SW:HEM2_STRCO (P54919) (330 aa) fasta scores: E(): 4.2e-76, 62.84% id in 323 aa, and to Escherichia coli delta-aminolevulinic acid dehydratase HemB or Ncf or B0369 SW:HEM2_ECOLI (P15002) (323 aa) fasta scores: E(): 3.6e-57, 50% id in 326 aa; Belongs to the ALAD family.
       0.543
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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