STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (294 aa)    
Predicted Functional Partners:
hemA
Putative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.999
DIP0402
Similar to Mycobacterium leprae possible uroporphyrin-III C-methyltransferase HemD or ML2420 TR:Q9CB60 (EMBL:AL583925) (563 aa) fasta scores: E(): 9.3e-91, 52.81% id in 551 aa.
 0.999
hemB
Similar to Streptomyces coelicolor delta-aminolevulinic acid dehydratase HemB or SCE68.09c SW:HEM2_STRCO (P54919) (330 aa) fasta scores: E(): 4.2e-76, 62.84% id in 323 aa, and to Escherichia coli delta-aminolevulinic acid dehydratase HemB or Ncf or B0369 SW:HEM2_ECOLI (P15002) (323 aa) fasta scores: E(): 3.6e-57, 50% id in 326 aa; Belongs to the ALAD family.
 
 0.999
DIP1484
Similar to Propionibacterium freudenreichii shermanii uroporphyrinogen III methyltransferase CobA TR:Q51720 (EMBL:U13043) (257 aa) fasta scores: E(): 1.6e-37, 47.05% id in 238 aa, and to Bacillus megaterium uroporphyrinogen III methylase CysGA TR:O87699 (EMBL:AJ000758) (243 aa) fasta scores: E(): 4.5e-32, 44.58% id in 240 aa.
  
 0.987
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.982
hemL
Similar to Streptomyces coelicolor glutamate-1-semialdehyde 2,1-aminomutase HemL or SCD65.12 SW:GSA_STRCO (Q9F2S0) (438 aa) fasta scores: E(): 4e-96, 62.97% id in 424 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL or Gsa or PopC or B0154 SW:GSA_ECOLI (P23893) (426 aa) fasta scores: E(): 1.7e-75, 52.39% id in 418 aa.
 
  
 0.943
hemH
Putative ferrochelatase (protoheme biosynthesis); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.757
DIP0399
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 10.7 kDa protein Rv0508 or MT0529 or MTCY20G9.35 SW:Y508_MYCTU (Q11172) (97 aa) fasta scores: E(): 2.7e-08, 40.74% id in 81 aa.
       0.673
hemG
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
  
 0.661
pgl
Putative phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
 
    
 0.615
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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