STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0402Similar to Mycobacterium leprae possible uroporphyrin-III C-methyltransferase HemD or ML2420 TR:Q9CB60 (EMBL:AL583925) (563 aa) fasta scores: E(): 9.3e-91, 52.81% id in 551 aa. (556 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
hemB
Similar to Streptomyces coelicolor delta-aminolevulinic acid dehydratase HemB or SCE68.09c SW:HEM2_STRCO (P54919) (330 aa) fasta scores: E(): 4.2e-76, 62.84% id in 323 aa, and to Escherichia coli delta-aminolevulinic acid dehydratase HemB or Ncf or B0369 SW:HEM2_ECOLI (P15002) (323 aa) fasta scores: E(): 3.6e-57, 50% id in 326 aa; Belongs to the ALAD family.
 
 
 0.999
hemA
Putative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.992
cobIJ
Similar to Mycobacterium tuberculosis cobalamin biosynthesis protein [includes: precorrin-2 C20-methyltransferase; precorrin-3 methylase] CobIJ or Rv2066 or MT2126 or MTCY49.05 SWALL:COBI_MYCTU (SWALL:Q10677) (508 aa) fasta scores: E(): 3.6e-88, 50.7% id in 495 aa, C-terminal region to Rhodobacter capsulatus precorrin-3 methylase SWALL:O68097 (EMBL:AF010496) (245 aa) fasta scores: E(): 1.1e-34, 48.14% id in 243 aa, and N-terminal region to Pseudomonas aeruginosa precorrin-2 methyltransferase CobI or PA2904 SWALL:Q9HZU3 (EMBL:AE004716) (250 aa) fasta scores: E(): 1.4e-33, 43.3% id in 254 aa.
  
 
 0.985
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.959
DIP1484
Similar to Propionibacterium freudenreichii shermanii uroporphyrinogen III methyltransferase CobA TR:Q51720 (EMBL:U13043) (257 aa) fasta scores: E(): 1.6e-37, 47.05% id in 238 aa, and to Bacillus megaterium uroporphyrinogen III methylase CysGA TR:O87699 (EMBL:AJ000758) (243 aa) fasta scores: E(): 4.5e-32, 44.58% id in 240 aa.
 
 
0.937
DIP1236
Similar to Mycobacterium tuberculosis precorrin-6Y C5,15-methyltransferase [decarboxylating] CobL or Rv2072c or MT2132 or MTCY49.11c SWALL:COBL_MYCTU (SWALL:Q10671) (390 aa) fasta scores: E(): 5.8e-57, 44.22% id in 398 aa, and to Pseudomonas denitrificans precorrin-6Y C5,15-methyltransferase [decarboxylating] CobL SWALL:COBL_PSEDE (SWALL:P21921) (413 aa) fasta scores: E(): 1.5e-47, 39.5% id in 405 aa.
  
  
 0.920
ribD
Putative riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.858
DIP2362
Putative iron-sulphur protein; Similar to Mycobacterium smegmatis Rieske iron-sulfur protein QcrA TR:Q9XBV4 (EMBL:AF155062) (138 aa) fasta scores: E(): 1.7e-11, 40.9% id in 132 aa, and to Streptomyces coelicolor putative iron-sulphur protein SCI51.03 TR:Q9S237 (EMBL:AL109848) (131 aa) fasta scores: E(): 3.8e-10, 35.15% id in 128 aa.
 
  
 0.827
DIP0414
Putative cytochrome C related protein; Similar to Mycobacterium tuberculosis CDC1551 cytochrome C assembly family protein MT0551 TR:AAK44774 (EMBL:AE006954) (324 aa) fasta scores: E(): 6.3e-54, 47.81% id in 320 aa.
  
    0.821
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (66%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.