STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
menCPutative O-succinylbenzoate-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (320 aa)    
Predicted Functional Partners:
menD
Putative menaquinone biosynthesis protein; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
  
 0.994
DIP0420
Putative ligase; Similar to Mycobacterium leprae O-succinylbenzoic acid-CoA ligase MenE or ML2257 TR:Q9CBB8 (EMBL:AL583924) (368 aa) fasta scores: E(): 7.1e-41, 43.71% id in 366 aa, and to Escherichia coli O-succinylbenzoic acid--CoA ligase MenE or B2260 SW:MENE_ECOLI (P37353) (451 aa) fasta scores: E(): 8.2e-14, 29.28% id in 379 aa.
 
 
  0.983
menB
Putative naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
 
   
 0.947
DIP0424
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 18.7 kDa protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 1.2e-11, 42.14% id in 121 aa.
 
     0.866
menH
Putative ubiquinone/menaquinone biosynthesis methlytransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
     
 0.863
DIP0425
Putative glycosyl transferase; Similar to Agrobacterium tumefaciens Agr_C_4173p TR:AAK88039 (EMBL:AE008145) (363 aa) fasta scores: E(): 1.9e-22, 31.8% id in 305 aa.
       0.842
menA
Probable 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
 
   
 0.683
tox
Diphtheria toxin precursor; Identical to previously sequenced Corynephage beta diphtheria toxin precursor SW:DTX_CORBE (P00588) (567 aa) fasta scores: E(): 6.2e-216, 100% id in 560 aa, and to Corynephage omega diphtheria toxin precursor SW:DTX_COROM (P00587) (560 aa) fasta scores: E(): 1.1e-215, 99.82% id in 560 aa. Note: The start codon for DIP0222 is 7 residues downstream of the one in Corynephage beta.
      
 0.583
DIP1114
Similar to Bacillus subtilis isochorismate synthase DhbC SW:DHBC_BACSU (P45744) (398 aa) fasta scores: E(): 1.9e-43, 41.01% id in 356 aa, and to Stigmatella aurantiaca MxcD TR:Q9F639 (EMBL:AF299336) (408 aa) fasta scores: E(): 7e-40, 36.91% id in 382 aa, and to Vibrio cholerae vibriobactin-specific isochorismate synthase VibC or VC0773 SW:VIBC_VIBCH (O07898) (395 aa) fasta scores: E(): 2.8e-31, 35.45% id in 330 aa.
 
   
 0.534
DIP0703
Putative oxidoreductase; Similar to Mycobacterium tuberculosis hypothetical 40.8 kDa protein Rv3230c or MTCY20B11.05c TR:O05875 (EMBL:Z95121) (380 aa) fasta scores: E(): 4.8e-60, 49.14% id in 350 aa, and to Escherichia coli NADH oxidoreductase Hcr or B0872 SW:HCR_ECOLI (P75824) (322 aa) fasta scores: E(): 1.9e-13, 28.71% id in 296 aa.
  
  
 0.413
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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