STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0425Putative glycosyl transferase; Similar to Agrobacterium tumefaciens Agr_C_4173p TR:AAK88039 (EMBL:AE008145) (363 aa) fasta scores: E(): 1.9e-22, 31.8% id in 305 aa. (341 aa)    
Predicted Functional Partners:
menD
Putative menaquinone biosynthesis protein; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
     
 0.890
menC
Putative O-succinylbenzoate-CoA synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
       0.842
DIP0424
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 18.7 kDa protein Rv0556 or MTCY25D10.35 TR:O06422 (EMBL:Z95558) (171 aa) fasta scores: E(): 1.2e-11, 42.14% id in 121 aa.
       0.842
menH
Putative ubiquinone/menaquinone biosynthesis methlytransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
       0.769
DIP1385
Conserved hypothetical protein; Similar to Mycobacterium leprae hypothetical 35.4 kDa protein ML0453 or MLCl581.15c SWALL:O07148 (EMBL:Z96801) (320 aa) fasta scores: E(): 5.5e-52, 47.33% id in 300 aa, and to Streptomyces coelicolor putative acyltransferase SCL2.16c SWALL:Q9L283 (EMBL:AL137778) (311 aa) fasta scores: E(): 1.4e-37, 43.44% id in 290 aa.
     
 0.766
menB
Putative naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
       0.714
glgB
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
   
 0.701
DIP0420
Putative ligase; Similar to Mycobacterium leprae O-succinylbenzoic acid-CoA ligase MenE or ML2257 TR:Q9CBB8 (EMBL:AL583924) (368 aa) fasta scores: E(): 7.1e-41, 43.71% id in 366 aa, and to Escherichia coli O-succinylbenzoic acid--CoA ligase MenE or B2260 SW:MENE_ECOLI (P37353) (451 aa) fasta scores: E(): 8.2e-14, 29.28% id in 379 aa.
       0.650
DIP0361
Putative bifunctional protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
  
  
 0.634
uvrD
Putative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa.
    
 
 0.626
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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