STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP0427Similar to Clostridium acetobutylicum lactate dehydrogenase CAC3552 TR:AAK81477 (EMBL:AE007851) (320 aa) fasta scores: E(): 1.6e-36, 38.6% id in 316 aa, and to Bacillus subtilis L-lactate dehydrogenase Ldh or LctE SW:LDH_BACSU (P13714) (320 aa) fasta scores: E(): 2.9e-25, 33.95% id in 324 aa; Belongs to the LDH/MDH superfamily. (316 aa)    
Predicted Functional Partners:
pyk
Pyruvate kinase; Similar to Corynebacterium glutamicum pyruvate kinase Pyk SW:KPYK_CORGL (Q46078) (475 aa) fasta scores: E(): 1.3e-146, 83.36% id in 469 aa, and to Bacillus psychrophilus pyruvate kinase Pyk SW:KPYK_BACPY (P51182) (586 aa) fasta scores: E(): 6.9e-64, 41.45% id in 480 aa.
  
 0.968
pyc
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
   
 0.932
DIP1952
Similar to Escherichia coli pyruvate dehydrogenase [cytochrome] PoxB SW:POXB_ECOLI (P07003) (572 aa) fasta scores: E(): 1.2e-100, 45.89% id in 573 aa, and to Streptomyces coelicolor pyruvate dehydrogenase SC1A9.19 TR:Q9ZBT3 (EMBL:AL034446) (580 aa) fasta scores: E(): 1.4e-132, 56.62% id in 581 aa; Belongs to the TPP enzyme family.
  
 0.927
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
  
 
0.921
aceE
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.909
sseA
Similar to Mycobacterium tuberculosis putative thiosulfate sulfurtransferase SseA or Rv3283 or MT3382 or MTCY71.23 SW:THT2_MYCTU (P96888) (297 aa) fasta scores: E(): 1.5e-78, 60.67% id in 295 aa, and to Corynebacterium glutamicum thiosulfate sulfurtransferase ThtR SW:THTR_CORGL (P71121) (225 aa) fasta scores: E(): 1.2e-56, 63.72% id in 215 aa.
   
 
  0.903
DIP1270
Pseudogene. Similar to Streptomyces coelicolor putative oxidoreductase SCM11.12c SWALL:Q9RIU9 (EMBL:AL133278) (500 aa) fasta scores: E(): 8.9e-41, 52.1% id in 428 aa. Presents multiple frameshifts at residues 33, 93, 121, 293 and 299.
   
 
  0.903
DIP2099
Putative sulfultransferase; Similar to Streptomyces coelicolor thiosulfate sulfurtransferase SC9B10.21 SWALL:O50528 (EMBL:AL009204) (283 aa) fasta scores: E(): 1.8e-28, 35% id in 280 aa, and to Pseudomonas aeruginosa probable 3-mercaptopyruvate sulfurtransferase SseA or PA1292 SWALL:THTM_PSEAE (SWALL:Q9I452) (284 aa) fasta scores: E(): 2.4e-28, 36.07% id in 280 aa.
   
 
  0.903
pgi
Similar to Escherichia coli glucose-6-phosphate isomerase Pgi or B4025 or Z5623 or ECS5008 SW:G6PI_ECOLI (P11537) (549 aa) fasta scores: E(): 2e-104, 52.71% id in 552 aa, and to Mycobacterium tuberculosis glucose-6-phosphate isomerase Pgi or Rv0946c or MT0972 or MTCY10D7.28 SW:G6PI_MYCTU (P77895) (553 aa) fasta scores: E(): 2.6e-133, 62.75% id in 545 aa.
  
 0.865
DIP2136
Putative aminotransferase; Similar to Mycobacterium tuberculosis probable aspartate aminotransferase AspC or Rv0337c or MT0351 or MTCY279.04c SW:AAT_MYCTU (O33267) (429 aa) fasta scores: E(): 2.4e-120, 71.32% id in 415 aa, and to Escherichia coli probable aminotransferase YfbQ or B2290 SW:YFBQ_ECOLI (P77727) (405 aa) fasta scores: E(): 1.8e-101, 61.59% id in 401 aa, and to Methylobacillus flagellatum aspartate aminotransferase Aat TR:Q9RAN0 (EMBL:L78665) (429 aa) fasta scores: E(): 1.7e-87, 55.08% id in 403 aa.
  
 0.843
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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