STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cstSHistidine kinase; Almost identical to already sequenced Corynebacterium diphtheriae histidine kinase CstS TR:Q9RPE8 (EMBL:AF161328) (408 aa) fasta scores: E(): 2e-149, 97.3% id in 408 aa. (408 aa)    
Predicted Functional Partners:
cstA
Response regulator; Identical to previously sequenced Corynebacterium diphtheriae response regulator CstA TR:Q9RPE7 (EMBL:AF161328) (233 aa) fasta scores: E(): 4.9e-83, 99.57% id in 233 aa.
 
 0.978
DIP0091
Putative two-component system response regulator; Similar to Streptomyces lividans response regulator homolog TR:P72471 (EMBL:U63847) (225 aa) fasta scores: E(): 2.7e-29, 42.98% id in 221 aa, and to Streptomyces coelicolor putative two-component system regulator SCH10.18c TR:Q9X8Q7 (EMBL:AL049754) (228 aa) fasta scores: E(): 3e-26, 38.53% id in 218 aa.
 
 0.870
chrA
Two-component response regulator ChrA; Previously sequenced and described as Corynebacterium diphtheriae response regulator ChrA SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.7e-67, 98.49% id in 199 aa. Similar to many eg. Streptomyces reticuli response regulatory protein SenR SWALL:Q9RIM0 (EMBL:Y14336) (217 aa) fasta scores: E(): 1.5e-28, 49.51% id in 204 aa.
 
 0.869
DIP2267
Similar to Streptomyces coelicolor putative two component system DNA binding response regulator SC10A9.12 SWALL:Q9AK92 (EMBL:AL583943) (211 aa) fasta scores: E(): 7.7e-38, 59.24% id in 211 aa, and to Corynebacterium diphtheriae response regulator ChrA (DIP2327) SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.1e-21, 49.76% id in 209 aa.
 
 0.868
DIP0600
Similar to Streptomyces coelicolor putative two-component system DNA-binding response regulator SSCD63A.03 TR:Q9KY72 (EMBL:AL356832) (251 aa) fasta scores: E(): 3.8e-26, 58.72% id in 235 aa, and to Bacillus brevis transcriptional regulatory protein DegU SW:DEGU_BACBR (P54662) (236 aa) fasta scores: E(): 2.7e-10, 30.97% id in 226 aa.
 
 0.863
DIP0460
Similar to Streptomyces coelicolor putative ABC transporter ATP-binding subunit 2SC6G5.39c TR:Q9K4B6 (EMBL:AL359152) (346 aa) fasta scores: E(): 9.6e-39, 44.02% id in 318 aa.
 
    0.758
DIP0461
Low similarity to Streptomyces coelicolor putative integral membrane protein SCBAC17A6.12c TR:CAC44657 (EMBL:AL596248) (387 aa) fasta scores: E(): 0.021, 30.04% id in 213 aa.
  
    0.747
DIP0463
Putative membrane protein; Similar to Streptococcus pyogenes hypothetical protein SPY0576 TR:Q9A0X1 (EMBL:AE006514) (300 aa) fasta scores: E(): 2.3e-31, 36.93% id in 287 aa.
  
    0.602
DIP0462
Putative membrane protein; No significant database matches.
       0.598
DIP0457
Hypothetical protein; No significant database matches.
       0.510
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.